Human MRGX2 Alexa Fluor® 488-conjugated Antibody

Datasheet / CoA / SDS
Product Details
  • Species Reactivity
  • Specificity
    Detects human MRGX2. Stains human MRGX2 transfectants but not irrelevant transfectants.
  • Source
    Monoclonal Mouse IgG2a Clone # 477533
  • Immunogen
    NS0 mouse myeloma cell line transfected with human MRGX2
    Accession # Q96LB1
  • Formulation
    Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
  • Label
    Alexa Fluor 488
Product Datasheets

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  • Intracellular Staining by Flow Cytometry
    0.25-1 µg/106 cells
    HEK293 human embryonic kidney cell line transfected with human MRGX2
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: MRGX2

MRGX2 (MAS-related GPR, member X2) is a 330 amino acid (aa) G-protein coupled 7-transmembrane protein that is selectively expressed in small-diameter sensory neurons of dorsal root ganglia. Human MRGX shares 41‑52% aa identity with three other primate MRGX proteins, but has no ortholog in rodents. Binding of ligands such as cortistatin, proadrenomedullin peptides (PAMP-12 and –20) and basic peptides (substance P, neuropeptide Y) to MRGX2 can activate Gq or Gi regulated pathways. MRGX2 is thought to influence nociception and promote adrenal gland catecholamine secretion and IgE-independent mast cell degranulation.

  • Long Name:
    Mas-related G Protein-coupled Receptor Member X2
  • Entrez Gene IDs:
    117194 (Human); 243978 (Mouse)
  • Alternate Names:
    MAS-related GPR, member X2; mas-related G-protein coupled receptor member X2; MRGPRX2; MRGX2; MRGX2G protein-coupled receptor MRGX2
Related Research Areas


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