Human NPDC-1 Antibody [Biotin]

NPDC-1 (Neural proliferation differentiation and control protein 1) is a 35 kDa member of the NPDC1/cab1 family of proteins. It is principally expressed in neurons, and serves as an anti-proliferation agent. It may accomplish this, in part, by binding to E2F-1 and blocking its protranscriptional activity. Mature human NPDC-1 is 291 amino acids (aa) in length. It is a type I transmembrane protein that contains an NLS (aa 107‑124), an HLH domain (aa 95‑128), a transmembrane domain (aa 182‑202), and a PEST degradation sequence (aa 269‑302). Phosphorylation promotes ubiquitination at this latter site. There are two splice variants. One shows a deletion of aa 242‑263, while another shows a nine aa substitution for the nine aa in positions 218‑226. Over aa 35‑181, human NPDC-1 shares 68% aa identity with mouse NPDC-1.