Human Phospho-Caveolin-1 (Y14) Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Caveolin-1

Caveolin-1 is a palmitoylated 22 kDa membrane-associated protein in caveolae, the cholesterol-rich invaginations in the plasma membrane involved in vesicular transport and regulation of lipid rafts. Caveolin-1 expression is dysregulated during cancer progression and exhibits both positive and negative effects on tumor progression. The central region of Caveolin-1 (aa 105‑125) is buried in the lipid layer, while the N- and C-terminal flanking regions are exposed to the cytoplasm and interact with many other proteins. Within these cytoplasmic regions, human Caveolin-1 shares 95% aa sequence identity with mouse and rat Caveolin-1. Alternate splicing in human, mouse and rat generates an isoform with a deletion of the N-terminal 31 residues.

Product Datasheets

Related Research Areas

• Actin Stress Fibers and Focal Adhesions During EMT
• Cancer Biomarkers
• Cell to Cell Adhesion Disassembly During EMT
• Focal Adhesions
• Lipid and Fatty Acid Transport
• Muscle Stem Cell Markers
• Myogenesis Markers
• Myogenic Precursor Markers
• Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway
• Uptake and Transport Molecules in VSMC
• Uptake and Transport Molecules on Endothelial Cells