Human PLC‑ beta 3 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: PLC-beta 3

The Phospholipase C family consists of 13 isozymes within six subfamilies, PLC-δ, -beta, -gamma, -epsilon, -zeta, and -eta. PLC-beta 3 (Phospholipase C beta-3) is a G-protein dependent phosphodiesterase that catalyzes the generation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4,5-bisphosphate (IP2), an essential step in the intracellular transduction of many extracellular signals. The PLC-beta subfamily consists of 4 isozymes, beta 1‑4, which differ in their tissue distribution and their ability to be activated by G proteins. PLC-beta 1 and PLC-beta 3 are more widely expressed, whereas PLC-beta 2 is resticted to hematopoietic cells and PLC-beta 4 is limited to certain neuronal cells and the retina.

Product Datasheets

Related Research Areas

• Bioactive Lipids and Receptors
• GDNF Family
• Intracellular Calcium Signaling in VSMC
• Lipid/Cholesterol Metabolism Enzymes
• Neurotrophin/Trk Family
• Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway
• Platelet Signaling
• Steroid Hormones and Bioactive Lipids