Human Presenilin-1 N-Terminal Fragment Biotinylated Antibody

Catalog # Availability Size / Price Qty
BAF149
Product Details
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Human Presenilin-1 N-Terminal Fragment Biotinylated Antibody Summary

Species Reactivity
Human
Specificity
Detects human Presenilin‑1 N‑Terminal Fragment in Western blots. In Western blots, less than 1% cross‑reactivity with recombinant human Presenilin‑1 C‑Terminal Fragment  (aa 298‑407) and recombinant human Presenilin‑2 C‑Terminal Fragment (aa 1‑80) is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human Presenilin‑1
Lys1-Lys80
Accession # P49768
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Label
Biotin

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human Presenilin‑1 N-Terminal Fragment

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Presenilin-1

Presenilin-1 is a catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). In addition it is required for normal embryonic brain and skeleton development, and for normal angiogenesis.

Entrez Gene IDs
5663 (Human)
Alternate Names
AD3EC 3.4.23.-; Alzheimer disease 3; EC 3.4.23; FAD; presenilin 1; Presenilin1; Presenilin-1; Protein S182; PS-1; PS1presenilin-1; PSEN1; PSNL1; S182

Product Datasheets

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