Home / PTPN14 / Human PTPN14 Alexa Fluor® 750-conjugated Antibody

Human PTPN14 Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB4458S Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB4458S-100UG

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Human PTPN14 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects endogenous human PTPN14 in Western blots. In Western blots, this antibody does not cross-react with recombinant human (rh) PTPN13 or rhPTPN22.
Source
Monoclonal Mouse IgG2b Clone # 448701
Purification
Protein A or G purified
Immunogen
E. coli-derived recombinant human PTPN14
Leu329-Leu900
Accession # Q15678.2
Formulation
Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Label
Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration
Sample
Western Blot
Optimal dilution of this antibody should be experimentally determined.
 
Immunohistochemistry
Optimal dilution of this antibody should be experimentally determined.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PTPN14

Protein Tyrosine Phosphatase, Non-receptor type 14 (PTPN14), also called Phosphatase with Ezrin Domain (PEZ) and PTP36, is a 135 kDa cytosolic protein that dephosphorylates tyrosine residues in proteins. PTPN14’s Ezrin domain is homologous to erythrocyte Band 4.1 protein, targeting the phosphatase to cytoskeletal elements such as actin. PTPN14 associates with beta-catenin in adhesion zones in cells that are touching, but is nuclear in isolated, proliferating cells. Loss-of-function mutations in PTPN14 are found in 26% of colorectal cancers, suggesting it is a tumor suppressor.

Long Name
Protein Tyrosine Phosphatase Non-receptor Type 14
Entrez Gene IDs
5784 (Human); 19250 (Mouse); 305064 (Rat)
Alternate Names
EC 3.1.3; EC 3.1.3.48; MGC126803; PEZ; PEZcytoskeletal-associated protein tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 14; Protein-tyrosine phosphatase pez; PTP36; PTPN14; tyrosine-protein phosphatase non-receptor type 14

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