Human/Rat DYRK1A Alexa Fluor™ Plus 405‑conjugated Antibody

R&D Systems | Catalog # AF5407AFP405

R&D Systems
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Key Product Details

Species Reactivity

Human, Rat

Applications

Immunohistochemistry, Western Blot, Immunoprecipitation

Label

Alexa Fluor Plus 405 (Excitation = 404 nm, Emission = 455 nm)

Antibody Source

Polyclonal Sheep IgG
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Product Specifications

Specificity

Detects human and rat DYRK1A in Western blots.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for Human/Rat DYRK1A Alexa Fluor™ Plus 405‑conjugated Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: DYRK1A

DYRK1A (Dual-specificity tyrosine [Y] phosphorylation regulated kinase 1A; also hMNB) is a member of the MNB/DYRK subfamily, CMGC Ser/Thr protein kinase family of enzymes. DYRK1A is ubiquitously expressed and shows dual substrate specificity. Autophosphorylation on Tyr321 leads to self-activation, while target proteins are Ser/Thr phosphorylated. Targets include APP, Tau, STAT3, and Cyclin L2. Human DYRK1A is 763 amino acids (aa) in length. It contains two NLSs (aa 69‑105 and 109-150), a kinase catalytic domain (aa 159-479), and C-terminal poly-Ser and poly-His regions. DYRK1A activity has been implicated in neuronal development and Down syndrome.

Long Name

Dual-specificity Tyrosine-[Y]-phosphorylation Regulated Kinase 1A

Alternate Names

MNBH

Entrez Gene IDs

1859 (Human); 13548 (Mouse); 25255 (Rat)

Gene Symbol

DYRK1A

UniProt

Additional DYRK1A Products

Product Documents for Human/Rat DYRK1A Alexa Fluor™ Plus 405‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human/Rat DYRK1A Alexa Fluor™ Plus 405‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Related Research Areas

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Protocols

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FAQs

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Associated Pathways

Notch Signaling Pathways
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