Human/Rat DYRK2 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB5408U Datasheet / COA / SDS

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FAB5408U-100UG

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Human/Rat DYRK2 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human, Rat

Specificity

Detects human and rat DYRK2 in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 599542

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human DYRK2
aa 1-107
Accession # NP_003574

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: DYRK2

DYRK2 (Dual-specificity tyrosine [Y] phosphorylation regulated kinase 2) is a 58‑62 kDa member of the MNB/DYRK subfamily, CMGC Ser/Thr protein kinase family of enzymes. It is expressed in testis and shows dual substrate specificity; autophosphorylation on Tyr382 to self‑activate, and a Ser/Thr phosphorylation of target molecules. Substrates include NFATc, glycogen synthase, and p53. p53 phosphorylation on Ser46 initiates cell apoptosis. Human DYRK2 is 601 amino acids (aa) in length. It contains one kinase catalytic domain (aa 222‑535). One isoform variant shows an alternate start site at Met74. This shorter isoform was used for immunization. Thus, over aa 1‑107 (or aa 74‑180 of the long form), human DYRK2 shares 93% aa identity with mouse DYRK2.

Long Name

Dual-specificity Tyrosine-[Y]-phosphorylation Regulated Kinase 2

Entrez Gene IDs

8445 (Human); 69181 (Mouse); 314862 (Rat)

Alternate Names

dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2; EC 2.7.12; EC 2.7.12.1; FLJ21217; FLJ21365