Human SCP3/SYCP3 Antibody

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Product Details
Citations (13)
Supplemental Products

Human SCP3/SYCP3 Antibody Summary

Species Reactivity
Detects human SCP3/SYCP3 in direct ELISAs and Western blots.
Polyclonal Goat IgG
Antigen Affinity-purified
E. coli-derived recombinant human SCP3/SYCP3
Accession # Q8IZU3
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human SCP3/SYCP3

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SCP3/SYCP3

SCP3 is a component of the synaptonemal complex, which is a meiosis-specific proteinaceous structure required for the pairing and segregation of homologous chromosomes. Human SCP3 is a 236 amino acid protein with a centrally located nuclear localization signal (NLS) and two C-terminal coiled coil domains. Human and mouse SCP3 share 71% amino acid sequence homology.

Long Name
Synaptonemal Complex Protein 3
Entrez Gene IDs
50511 (Human); 20962 (Mouse); 25561 (Rat)
Alternate Names
COR1; MGC71888; SCP3 chromosome 3 open reading frame 8; SCP3 COR1; SCP3; SCP-3; SYCP3; synaptonemal complex protein 3

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Citations for Human SCP3/SYCP3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

13 Citations: Showing 1 - 10
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  1. Novel Hemizygous Mutations of TEX11 Cause Meiotic Arrest and Non-obstructive Azoospermia in Chinese Han Population
    Authors: Zhiyong Ji, Chencheng Yao, Chao Yang, Chuan Huang, Liangyu Zhao, Xia Han et al.
    Frontiers in Genetics
  2. Distinct prophase arrest mechanisms in human male meiosis
    Authors: Sabrina Z. Jan, Aldo Jongejan, Cindy M. Korver, Saskia K. M. van Daalen, Ans M. M. van Pelt, Sjoerd Repping et al.
  3. ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis
    Authors: Shao, Q;Zhang, Y;Liu, Y;Shang, Y;Li, S;Liu, L;Wang, G;Zhou, X;Wang, P;Gao, J;Zhou, J;Zhang, L;Wang, S;
    Cell reports
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  4. Retinoic acid-induced differentiation of porcine prospermatogonia in�vitro
    Authors: X You, T Li, Y Cui, W Liu, Z Cheng, W Zeng, P Wang, Y Zheng
    Theriogenology, 2023-01-07;198(0):344-355.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: ICC
  5. Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation
    Authors: H Abe, YH Yeh, Y Munakata, KI Ishiguro, PR Andreassen, SH Namekawa
    Nature Communications, 2022-11-28;13(1):7212.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  6. Novel copy number variations within SYCE1 caused meiotic arrest and non-obstructive azoospermia
    Authors: Y Huang, R Tian, J Xu, Z Ji, Y Zhang, L Zhao, C Yang, P Li, E Zhi, H Bai, S Han, J Luo, J Zhao, J Zhang, Z Zhou, Z Li, C Yao
    BMC medical genomics, 2022-06-19;15(1):137.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  7. SETDB1 Regulates Porcine Spermatogonial Adhesion and Proliferation through Modulating MMP3/10 Transcription
    Authors: R Liu, Z Liu, M Guo, W Zeng, Y Zheng
    Cells, 2022-01-22;11(3):.
    Species: Porcine
    Sample Types: Whole Tissue
    Applications: IHC
  8. Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase
    Authors: JA Slotman, MW Paul, F Carofiglio, HM de Gruiter, T Vergroesen, L Koornneef, WA van Cappel, AB Houtsmulle, WM Baarends
    PLoS Genet., 2020-06-05;16(6):e1008595.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis
    Authors: I Brandsma, K Sato, SE van Rossum, N van Vliet, E Sleddens, M Reuter, H Odijk, N van den Te, DHW Dekkers, K Bezstarost, JAA Demmers, A Maas, J Lebbink, C Wyman, J Essers, DC van Gent, WM Baarends, P Knipscheer, R Kanaar, AN Zelensky
    Cell Rep, 2019-06-25;27(13):3790-3798.e7.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  10. Repair of exogenous DNA double-strand breaks promotes chromosome synapsis in SPO11-mutant mouse meiocytes, and is altered in the absence of HORMAD1
    Authors: F Carofiglio, E Sleddens-L, E Wassenaar, A Inagaki, WA van Cappel, JA Grootegoed, A Toth, WM Baarends
    DNA Repair (Amst.), 2018-01-31;63(0):25-38.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  11. Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation.
    Authors: Yamano N, Kimura T, Watanabe-Kushima S, Shinohara T, Nakano T
    Biochem. Biophys. Res. Commun., 2010-01-06;392(3):311-6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  12. Novel bi-allelic MSH4 variants causes meiotic arrest and non-obstructive azoospermia
    Authors: Peng Li, Zhiyong Ji, Erlei Zhi, Yuxiang Zhang, Sha Han, Liangyu Zhao et al.
    Reproductive Biology and Endocrinology
  13. Bi-allelic SHOC1 loss-of-function mutations cause meiotic arrest and non-obstructive azoospermia
    Authors: Chencheng Yao, Chao Yang, Liangyu Zhao, Peng Li, Ruhui Tian, Huixing Chen et al.
    Journal of Medical Genetics


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