Signal regulatory protein alpha (SIRP alpha, designated CD172a), also called SHPS-1 (SHP substrate 1), BIT (Brain Ig-like molecule with Tyrosine-based activation motifs) and previously, MyD-1 (Myeloid/Dendritic-1), is a transmembrane glycoprotein belonging to the SIRP/SHPS (CD172) family within the immunoglobulin superfamily. SIRP alpha contains cytoplasmic ITIM domains and produces negative regulatory signals. Through adhesion to CD47/IAP (integrin-associated protein), SIRP alpha inhibits clearance of CD47high young erythrocytes and platelets and promotes macrophage fusion during osteoclastogenesis. SIRP alpha recognition of surfactants SP-A and SP-D in the lung can inhibit alveolar macrophage cytokine production.
Human SIRP alpha/CD172a (NP_542970) VersaClone cDNA
R&D Systems | Catalog # RDC1920
Loading...
Loading...
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: SIRP alpha/CD172a
Long Name
Signal-regulatory Protein alpha
Alternate Names
BIT, CD172a, MFR, MYD-1, SHPS1, SIRPA
Entrez Gene IDs
Gene Symbol
SIRPA
UniProt
Additional SIRP alpha/CD172a Products
Product Documents for Human SIRP alpha/CD172a (NP_542970) VersaClone cDNA
Product Specific Notices for Human SIRP alpha/CD172a (NP_542970) VersaClone cDNA
For research use only
Customer Reviews for Human SIRP alpha/CD172a (NP_542970) VersaClone cDNA
There are currently no reviews for this product. Be the first to review Human SIRP alpha/CD172a (NP_542970) VersaClone cDNA and earn rewards!
Have you used Human SIRP alpha/CD172a (NP_542970) VersaClone cDNA?
Submit a review and receive an Amazon gift card!
$25/€18/£15/$25CAN/¥2500 Yen for a review with an image
$10/€7/£6/$10CAN/¥1110 Yen for a review without an image
Submit a review
