Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Biotin

Antibody Source

Polyclonal Sheep IgG
View all Stabilin-1 Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human Stabilin-1
Gly2208-Val2305
Accession # ABG91068

Specificity

Detects human Stabilin-1 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human Stabilin-2 is observed.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for Human Stabilin-1 Biotinylated Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Human Stabilin‑1

Reviewed Applications

Read 1 review rated 5 using BAF3825 in the following applications:

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Stabilin-1

Stabilin-1, also known as FEEL-1 (fasciclin, EGF-like, laminin type EGF-like, and link domain containing scavenger receptor 1) and CLEVER-1 (common lymphatic endothelial and vascular endothelial receptor 1), was originally identified as the MS-1 antigen. It is a type I transmembrane multi-domain protein with a large extracellular domain that contains 7 fasciclin, multiple EGF-like and laminin type EGF-like, and a link domain. The short cytoplasmic tail interacts with CGAs which are cargo adaptors that link cargo into the clathrin-coated pits. Stabilin-1 is expressed by tissue macrophages and sinusoidal endothelial cells, which are scavenging cells. Stabilin-1 is involved in intracellular trafficking pathways and binds multiple ligands including acetylated LDL, SPARC, AGE, and SI-CLP. By alternative splicing, a soluble Stabilin-1 containing a 58 residue substitution between amino acid residues 746 and 803, followed by truncation, has been identified. Within the region used as immunogen, human Stabilin-1 shares 83% and 84% amino acid sequence homology with mouse and canine Stabilin-1, respectively.

Alternate Names

CLEVER-1, FEEL-1, FELE-1, FEX1, MS-1 Antigen, STAB1, Stabilin1

Entrez Gene IDs

23166 (Human); 192187 (Mouse); 290559 (Rat)

Gene Symbol

STAB1

UniProt

ABG91068

Additional Stabilin-1 Products

Product Documents for Human Stabilin-1 Biotinylated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Stabilin-1 Biotinylated Antibody

For research use only

Customer Reviews for Human Stabilin-1 Biotinylated Antibody (1)

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  • Human Stabilin-1 Biotinylated Antibody
    Name: Anonymous
    Application: Flow Cytometry
    Sample Tested: monocyte-derived macrophages polarized to M2-like phenotype
    Species: Human
    Verified Customer | Posted 08/13/2024
    Stabilin-1 expression on human monocyte-derived macrophages polarized to M2-like phenotype. 5 μl of the Stabilin-1 antibody (blue) or sheep IgG biotinylated ctr antibody (red) followed by 5 μl of streptavidin PE were used.
    Human Stabilin-1 Biotinylated Antibody BAF3825

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