Human Stanniocalcin 2/STC-2 Antibody

Catalog # Availability Size / Price Qty
AF2830
AF2830-SP
Detection of Human Stanniocalcin 2/STC-2 by Immunohistochemistry
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Product Details
Citations (4)
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Human Stanniocalcin 2/STC-2 Antibody Summary

Species Reactivity
Human
Specificity
Detects human and mouse Stanniocalcin 2/STC‑2 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human STC-1 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Stanniocalcin 2/STC‑2
Thr25-Arg302
Accession # O76061
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human Stanniocalcin 2/STC‑2

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry Detection of Human Stanniocalcin 2/STC-2 by Immunohistochemistry View Larger

Detection of Human Stanniocalcin 2/STC-2 by Immunohistochemistry STC2 expression in tumor adjacent nasopharyngeal epithelia with normal morphology and carcinoma cells as determined by immunohistochemistry studies. A: STC2 expressed in local tumor (× 200). B: Traditional HE staining, NPC, (× 200). C: STC2 was overexpressed in the tumor zone (× 100). D: Negative Control: NPC tissue stained at the same conditions except that no specific antibody (anti-STC2) was added (× 100). Scale bar: 50 μm in A and B; 100 μm in C and D. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/24606961), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Human Stanniocalcin 2/STC-2 by Immunohistochemistry View Larger

Detection of Human Stanniocalcin 2/STC-2 by Immunohistochemistry STC2 expression in tumor adjacent nasopharyngeal epithelia with normal morphology and carcinoma cells as determined by immunohistochemistry studies. A: STC2 expressed in local tumor (× 200). B: Traditional HE staining, NPC, (× 200). C: STC2 was overexpressed in the tumor zone (× 100). D: Negative Control: NPC tissue stained at the same conditions except that no specific antibody (anti-STC2) was added (× 100). Scale bar: 50 μm in A and B; 100 μm in C and D. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/24606961), licensed under a CC-BY license. Not internally tested by R&D Systems.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Stanniocalcin 2/STC-2

STC-2 is a secreted disulfide-linked homodimeric glycoprotein hormone that is related to the STC protein first discovered from corpuscles of stannius in fish. STC2 is expressed in a wide variety of tissues. In the ovary, STC2 has been shown to be a paracrine hormone that regulates granulosa cell function. The amino acid sequence of human mature STC2 is 36% identical to that of human STC1. It is also 99%, and 88% identical to that of mature monkey and mouse STC2, respectively.

Entrez Gene IDs
8614 (Human); 20856 (Mouse)
Alternate Names
Stanniocalcin 2; stanniocalcin-2; STC2; STC-2; STC-2Stanniocalcin-related protein; STC-related protein; STCRP

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Citations for Human Stanniocalcin 2/STC-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Rare and low-frequency coding variants alter human adult height
    Authors: E Marouli, M Graff, C Medina-Gom, KS Lo, AR Wood, TR Kjaer, RS Fine, Y Lu, C Schurmann, HM Highland, S Reger, G Thorleifss, AE Justice, D Lamparter, KE Stirrups, V Turcot, KL Young, TW Winkler, T Esko, T Karaderi, AE Locke, NG Masca, MC Ng, P Mudgal, MA Rivas, S Vedantam, A Mahajan, X Guo, G Abecasis, KK Aben, LS Adair, DS Alam, E Albrecht, KH Allin, M Allison, P Amouyel, EV Appel, D Arveiler, FW Asselbergs, PL Auer, B Balkau, B Banas, LE Bang, M Benn, S Bergmann, LF Bielak, M Blher, H Boeing, E Boerwinkle, CA B”ger, LL Bonnycastl, J Bork-Jense, ML Bots, EP Bottinger, DW Bowden, I Brandslund, G Breen, MH Brilliant, L Broer, AA Burt, AS Butterwort, DJ Carey, MJ Caulfield, JC Chambers, DI Chasman, YI Chen, R Chowdhury, C Christense, AY Chu, M Cocca, FS Collins, JP Cook, J Corley, JC Galbany, AJ Cox, G Cuellar-Pa, J Danesh, G Davies, PI de Bakker, GJ de Borst, S de Denus, MC de Groot, R de Mutsert, IJ Deary, G Dedoussis, EW Demerath, AI den Hollan, JG Dennis, E Di Angelan, F Drenos, M Du, AM Dunning, DF Easton, T Ebeling, TL Edwards, PT Ellinor, P Elliott, E Evangelou, AE Farmaki, JD Faul, MF Feitosa, S Feng, E Ferrannini, MM Ferrario, J Ferrieres, JC Florez, I Ford, M Fornage, PW Franks, R Frikke-Sch, TE Galesloot, W Gan, I Gandin, P Gasparini, V Giedraitis, A Giri, G Girotto, SD Gordon, P Gordon-Lar, M Gorski, N Grarup, ML Grove, V Gudnason, S Gustafsson, T Hansen, KM Harris, TB Harris, AT Hattersley, C Hayward, L He, IM Heid, K Heikkil„, ? Helgeland, J Hernesniem, AW Hewitt, LJ Hocking, M Hollensted, OL Holmen, GK Hovingh, JM Howson, CB Hoyng, PL Huang, K Hveem, MA Ikram, E Ingelsson, AU Jackson, JH Jansson, GP Jarvik, GB Jensen, MA Jhun, Y Jia, X Jiang, S Johansson, ME J?rgensen, T J?rgensen, P Jousilahti, JW Jukema, B Kahali, RS Kahn, M K„h”nen, PR Kamstrup, S Kanoni, J Kaprio, M Karalefthe, SL Kardia, F Karpe, F Kee, R Keeman, LA Kiemeney, H Kitajima, KB Kluivers, T Kocher, P Komulainen, J Kontto, JS Kooner, C Kooperberg, P Kovacs, J Kriebel, H Kuivaniemi, S Kry, J Kuusisto, M La Bianca, M Laakso, TA Lakka, EM Lange, LA Lange, CD Langefeld, C Langenberg, EB Larson, IT Lee, T Lehtim„ki, CE Lewis, H Li, J Li, R Li-Gao, H Lin, LA Lin, X Lin, L Lind, J Lindstr”m, A Linneberg, Y Liu, Y Liu, A Lophatanan, J Luan, SA Lubitz, LP Lyytik„ine, DA Mackey, PA Madden, AK Manning, S M„nnist”, G Marenne, J Marten, NG Martin, AL Mazul, K Meidtner, A Metspalu, P Mitchell, KL Mohlke, DO Mook-Kanam, A Morgan, AD Morris, AP Morris, M Mller-Nur, PB Munroe, MA Nalls, M Nauck, CP Nelson, M Neville, SF Nielsen, K Nikus, PR Nj?lstad, BG Nordestgaa, I Ntalla, JR O'Connel, H Oksa, LM Loohuis, RA Ophoff, KR Owen, CJ Packard, S Padmanabha, CN Palmer, G Pasterkamp, AP Patel, A Pattie, O Pedersen, PL Peissig, GM Peloso, CE Pennell, M Perola, JA Perry, JR Perry, TN Person, A Pirie, O Polasek, D Posthuma, OT Raitakari, A Rasheed, R Rauramaa, DF Reilly, AP Reiner, F Renstr”m, PM Ridker, JD Rioux, N Robertson, A Robino, O Rolandsson, I Rudan, KS Ruth, D Saleheen, V Salomaa, NJ Samani, K Sandow, Y Sapkota, N Sattar, MK Schmidt, PJ Schreiner, MB Schulze, RA Scott, MP Segura-Lep, S Shah, X Sim, S Sivapalara, KS Small, AV Smith, JA Smith, L Southam, TD Spector, EK Speliotes, JM Starr, V Steinthors, HM Stringham, M Stumvoll, P Surendran, LM 't Hart, KE Tansey, JC Tardif, KD Taylor, A Teumer, DJ Thompson, U Thorsteins, BH Thuesen, A T”njes, G Tromp, S Trompet, E Tsafantaki, J Tuomilehto, A Tybjaerg-H, JP Tyrer, R Uher, AG Uitterlind, S Ulivi, SW van der La, AR Van Der Le, CM van Duijn, NM van Schoor, J van Setten, A Varbo, TV Varga, R Varma, DR Edwards, SH Vermeulen, H Vestergaar, V Vitart, TF Vogt, D Vozzi, M Walker, F Wang, CA Wang, S Wang, Y Wang, NJ Wareham, HR Warren, J Wessel, SM Willems, JG Wilson, DR Witte, MO Woods, Y Wu, H Yaghootkar, J Yao, P Yao, LM Yerges-Arm, R Young, E Zeggini, X Zhan, W Zhang, JH Zhao, W Zhao, W Zhao, H Zheng, W Zhou, JI Rotter, M Boehnke, S Kathiresan, MI McCarthy, CJ Willer, K Stefansson, IB Borecki, DJ Liu, KE North, NL Heard-Cost, TH Pers, CM Lindgren, C Oxvig, Z Kutalik, F Rivadeneir, RJ Loos, TM Frayling, JN Hirschhorn, P Deloukas, G Lettre
    Nature, 2017-02-01;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Western Blot
  2. Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A.
    Authors: Kloverpris S, Mikkelsen J, Pedersen J, Jepsen M, Laursen L, Petersen S, Oxvig C
    J Biol Chem, 2015-07-20;290(36):21915-24.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  3. Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis.
    Authors: Jepsen M, Kloverpris S, Mikkelsen J, Pedersen J, Fuchtbauer E, Laursen L, Oxvig C
    J Biol Chem, 2014-12-22;290(6):3430-9.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  4. Survival analyses correlate stanniocalcin 2 overexpression to poor prognosis of nasopharyngeal carcinomas.
    Authors: Lin S, Guo Q, Wen J, Li C, Lin J, Cui X, Sang N, Pan J
    J Exp Clin Cancer Res, 2014-03-08;33(0):26.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC

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