Human STIM1 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: STIM1

STIM-1 (stromal interaction molecule 1), previously called GOK, is a 90 kDa type I transmembrane protein of the endoplasmic reticulum (ER). When STIM-1 senses depletion of calcium in the ER via its EF-hand domain (aa 63-98), it interacts with the plasma membrane Ca2⁺ release-activated Ca2⁺ (CRAC) channel Orai1, increasing Ca2⁺ influx. The human STIM-1 extracellular/lumenal domain (aa 23-213) contains an EF hand Ca2⁺-binding motif and a SAM (sterile a-motif) multimerization domain. A potential isoform is truncated at aa 491. Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2). Within the region used as an immunogen, human STIM1 shares 95% amino acid identity with mouse and rat STIM1.

Product Datasheets

Related Research Areas

• Calcium Channels
• Dense Granule Molecules
• Ion Channels and Regulators
• Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway
• Platelet Cytoskeleton and Granule Release
• Platelet Lysosome Molecules