Human Tau MAb (Clone 376720)

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Tau

Tau protein is named for its ability to serve as a bridge for microtubule formation and stabilization. Tau in PNS neurons is 758 amino acids (aa) in length and 110 kDa in size. It migrates anomalously in SDS-PAGE. Its N-terminus binds plasma membrane components while its C‑terminus binds microtubules. The microtubule-binding region contains four consecutive Tau/MAP repeats between aa 561‑685. Each repeat is 30 aa long, Ser/Thr rich, and shows a PGGG motif. Multiple isoforms exist, ranging from 316 to 776 aa in length. Various deletions occur within the first 500 aa, with some isoforms also showing an absence of the second Tau repeat (aa 592‑622). Between aa 624‑756, human Tau protein shows absolute identity to mouse and dog Tau.

Product Datasheets

Related Research Areas

• Cancer Biomarkers
• Cell Structure and Signaling Molecules
• Diabetic Peripheral Neuropathy
• Microtubules
• Neurofibrillary Tangle Formation
• Neuronal Lineage Markers
• Neuronal Markers
• Synaptic Proteins