Human TFPI-2 Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: TFPI-2

Human Tissue Factor Pathway Inhibitor 2 (TFPI-2), also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF-1), is a secreted protein with an N-terminal acidic region, three Kunitz (K) domains (amino acids 36 to 86, 96 to 149 and 158 to 208) separated with by two linker regions, and a C-terminal basic region (1‑3). It is a Kunitz-type serine protease inhibitor secreted by all cells of the vasculature (endothelial cells, smooth muscle cells, and fibroblasts) into the extracellular matrix (ECM), where it plays a role in the regulation of urokinase/plasmin-mediated ECM turnover. Expression of TFPI-2 is down-regulated in several cancers, which may contribute to tumor progression in these cancers (4).

Product Datasheets

Related Research Areas

• Coagulation
• Serine Proteases and Regulators