Human TMEM59 Alexa Fluor® 532-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: TMEM59

TMEM59 is a 324 aa protein with a 21 amino acid transmembrane domain which localizes to the Golgi compartment where it modulates the O-glycosylation and complex N-glycosylation maturation steps of several proteins including APP, BACE1, SEAP and PRNP. It may retain APP in the Golgi and inhibits amyloid beta generation as well APP cleavage by alpha and beta secretases. TMEM59 also contains a 19 aa peptide that acts as a regulator of autophagy in response to bacterial infection by promoting LC3 activation through interaction with ATG16L1, targeting its own endosomal compartment to lysosomes in response to aggregation during S.areus infection.

Product Datasheets

Related Research Areas

• APP Processing and Amyloid Plaque Formation
• Autophagy