Human TRAIL/TNFSF10 PE-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB687P
Human TRAIL/TNFSF10 PE-conjugated Antibody in Data
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Product Details
Citations (5)
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Human TRAIL/TNFSF10 PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human TRAIL in direct ELISAs.
Source
Monoclonal Mouse IgG1 Clone # 75402
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TRAIL
Thr95-Gly281
Accession # P50591
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry Detection of TRAIL/TNFSF10 antibody in Human PBMCs antibody by Flow Cytometry. View Larger

Detection of TRAIL/TNFSF10 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs), untreated (A) or treated (B) with rhIFN- a for 48 hours (150 ng/mL), were stained with Mouse Anti-Human TRAIL/TNFSF10 PE-conjugated Monoclonal Antibody (Catalog # FAB687P) and Mouse Anti-Human CD14 APC-conjugated Monoclonal Antibody (Catalog # 3832A). Quadrant markers were set based on control antibody staining (Catalog # IC002P).

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: TRAIL/TNFSF10

TRAIL is a type II transmembrane protein belonging to the TNF superfamily and is now designated TNFSF10. TRAIL is active as a homotrimer and is produced by a variety of cell types in both the membrane bound form and also as a soluble molecule. It binds to any of the four TRAIL receptors as well as to Osteoprotegerin.

Long Name
TNF-related Apoptosis-inducing Ligand
Entrez Gene IDs
8743 (Human); 22035 (Mouse); 246775 (Rat)
Alternate Names
Apo-2 ligand; APO2L; Apo-2Ltumor necrosis factor (ligand) family, member 10; APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta; CD253 antigen; CD253; Protein TRAIL; TL2; TNF-related apoptosis-inducing ligand; TNFSF10; TRAIL; TRAILTNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor ligand superfamily member 10

Citations for Human TRAIL/TNFSF10 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Defective Regulation of Membrane TNF&alpha Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells
    Authors: T Tyrinova, O Leplina, S Mishinov, M Tikhonova, E Dolgova, A Proskurina, V Stupack, S Bogachev, A Ostanin, E Chernykh
    Int J Mol Sci, 2020;21(8):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-?-dependent emperipolesis in HBV cirrhotic patients
    Authors: J Shi, J Zhao, X Zhang, Y Cheng, J Hu, Y Li, X Zhao, Q Shang, Y Sun, B Tu, L Shi, B Gao, FS Wang, Z Zhang
    Sci Rep, 2017;7(0):44544.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Peg-Interferon Lambda Treatment Induces Robust Innate and Adaptive Immunity in Chronic Hepatitis B Patients
    Authors: S Phillips, S Mistry, A Riva, H Cooksley, T Hadzhiolov, S Plavova, K Katzarov, M Simonova, S Zeuzem, C Woffendin, PJ Chen, CY Peng, TT Chang, S Lueth, R De Knegt, MS Choi, H Wedemeyer, M Dao, CW Kim, HC Chu, M Wind-Rotol, R Williams, E Cooney, S Chokshi
    Front Immunol, 2017;8(0):621.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection.
    Authors: Golden-Mason L, Hahn Y, Strong M, Cheng L, Rosen H
    PLoS ONE, 2014;9(7):e103219.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity.
    Authors: Kalb ML, Glaser A, Stary G, Koszik F, Stingl G
    J. Immunol., 2012;188(4):1583-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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