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Human Vanilloid R-like 3/TRPV3 Antibody

Catalog #: AF4167 Datasheet / COA / SDS

Discontinued Product

AF4167 has been discontinued.
View all Vanilloid R-like 3/TRPV3 products.
Vanilloid R-like 3/TRPV3 in Human Skin.
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Human Vanilloid R-like 3/TRPV3 Antibody Summary

Species Reactivity
Human
Specificity
Detects human VRL-3 in immunohistochemistry.
Source
Polyclonal Sheep IgG
Purification
Antigen Affinity-purified
Immunogen
KLH-coupled human Vanilloid R-like 3 synthetic peptide
KEMVPLMGKR
Accession # Q8NET8
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Immunohistochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry Vanilloid R-like 3/TRPV3 antibody in Human Skin by Immunohistochemistry (IHC-P). View Larger

Vanilloid R-like 3/TRPV3 in Human Skin. Vanilloid R-like 3/TRPV3 was detected in immersion fixed paraffin-embedded sections of human skin using 15 µg/mL Human Vanilloid R-like 3/TRPV3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4167) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Vanilloid R-like 3/TRPV3

Vanilloid Receptor-like 3 (VRL-3), also known as transient receptor potential cation channel subfamily V3 (TRPV3) is a 70 kDa member of the vanilloid receptor/TRP gene family. It is expressed on keratinocytes and neurons, and is physiologically responsive to changes in temperature between 22-40° C. Human TRPV3 is 790 amino acids (aa) in length. It is a 6 transmembrane domain protein that contains an N- and C-terminal cytoplasmic region. Three ankyrin repeats occur in the extended N-terminal cytoplasmic region (aa 214-369). There is one alternate splice form that shows a 6 aa substituton for the C-terminal 31 amino acids. Over amino acids 6‑15, human TRPV3 shares 90% aa sequence identity with mouse and canine TRPV3.

Long Name
Vanilloid Receptor Like 3/Transient Receptor Potential Cation Channel 3
Entrez Gene IDs
162514 (Human); 246788 (Mouse); 497948 (Rat)
Alternate Names
transient receptor potential cation channel subfamily V member 3; transient receptor potential cation channel, subfamily V, member 3; TRPV3; vanilloid receptor 3; Vanilloid receptor-like 3; vanilloid receptor-related osmotically activated channel protein; Vanilloid R-like 3; VanilloidR like 3; VanilloidR-like3; VRL3; VRL-3

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