Human VE-Cadherin PE-conjugated Antibody Summary
Asp48-Gln593
Accession # P33151
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data

Detection of VE‑Cadherin in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were stained with Mouse Anti-Human VE-Cadherin PE-conjugated Monoclonal Antibody (Catalog # FAB9381P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). Cells were stained in a buffer containing Ca2+and Mg2+. View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: VE-Cadherin
Vascular endothelial (VE)-Cadherin (VE-CAD), also called 7B4 and Cadherin‑5 (CDH5), is a member of the cadherin family of cell adhesion molecules. Cadherins are calcium-dependent transmembrane proteins which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, alpha, beta, and gamma (plakoglobin). This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. VE-Cadherin has been shown to play important roles in vasculogenesis and angiogenesis. VE-Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. Human VE-Cadherin is a 784 amino acid (aa) residue protein with a 25 aa signal sequence and a 759 aa propeptide. The mature protein begins at amino acid 48 and has a 546 aa extracellular domain, a 27 aa transmembrane domain, and a 164 aa cytoplasmic domain. The human and mouse mature VE-Cadherin proteins share approximately 74% homology.
- Shimoyama, Y. et al. (1989) J. Cell Biol. 109:1787.
- Bussemakers, M.J.G. et al. (1993) Mol. Biol. Reports 17:123.
- Overduin, M. et al. (1995) Science 267:386.
- Takeichi, M. (1991) Science 251:1451.
- Nose, A. et al. (1987) EMBO J. 6:3655.
- Carmeliet, P. et al. (1999) Cell 98:147.
- Gory-Faure, S. et al. (1999) Development 126:2093.
Product Datasheets
Citations for Human VE-Cadherin PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures
Authors: J Kelleher, A Dickinson, S Cain, Y Hu, N Bates, A Harvey, J Ren, W Zhang, FC Moreton, KW Muir, C Ward, RM Touyz, P Sharma, Q Xu, SJ Kimber, T Wang
Stem Cell Reports, 2019;13(5):817-831.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Preparation of iPS cell-derived CD31+ endothelial cells using three-dimensional suspension culture
Authors: S Masuda, K Matsuura, T Shimizu
Regen Ther, 2018;9(0):1-9.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Effect of intensive multifactorial treatment on vascular progenitor cells in hypertensive patients
Authors: C Maroun-Eid, A Ortega-Her, J Modrego, M Abad-Cardi, JA García-Don, L Reinares, N Martell-Cl, D Gómez-Garr
PLoS ONE, 2018;13(1):e0190494.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in�Sturge-Weber Syndrome
Authors: Lan Huang
Pediatr. Neurol, 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Glucose transporter 1-positive endothelial cells in infantile hemangioma exhibit features of facultative stem cells.
Authors: Huang L, Nakayama H, Klagsbrun M, Mulliken J, Bischoff J
Stem Cells, 2015;33(1):133-45.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells.
Authors: White M, Rufaihah A, Liu L, Ghebremariam Y, Ivey K, Cooke J, Srivastava D
Stem Cells, 2013;31(1):92-103.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
Authors: Pelosi E, Castelli G, Martin-Padura I, Bordoni V, Santoro S, Conigliaro A, Cerio A, De Santis Puzzonia M, Marighetti P, Biffoni M, Alonzi T, Amicone L, Alcalay M, Bertolini F, Testa U, Tripodi M
PLoS ONE, 2012;7(12):e51109.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Successful In Vitro Expansion and Differentiation of Cord Blood Derived CD34+ Cells into Early Endothelial Progenitor Cells Reveals Highly Differential Gene Expression.
Authors: Ahrens I, Domeij H, Topcic D
PLoS ONE, 2011;6(8):e23210.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.
Authors: Ricci-Vitiani L, Pallini R, Biffoni M, Todaro M, Invernici G, Cenci T, Maira G, Parati EA, Stassi G, Larocca LM, De Maria R
Nature, 2010;468(7325):824-8.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A.
Authors: Narazaki M, Segarra M, Tosato G
Blood, 2008;111(8):4126-36.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages.
Authors: Porat Y, Porozov S, Belkin D, Shimoni D, Fisher Y, Belleli A, Czeiger D, Silverman WF, Belkin M, Battler A, Fulga V, Savion N
Br. J. Haematol., 2006;135(5):703-14.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Structural and functional studies of the endothelial activation antigen endothelial leucocyte adhesion molecule-1 using a panel of monoclonal antibodies.
Authors: Pigott R, Needham LA, Edwards RM
J. Immunol., 1991;147(1):130-5.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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