Human VEGF-C Biotinylated Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (2)
Supplemental Products

Human VEGF-C Biotinylated Antibody Summary

Species Reactivity
Detects human VEGF-C in Western blots. In this format, less than 1% cross‑reactivity is observed with rhVEGF121 and rhVEGF165b.
Polyclonal Goat IgG
Antigen Affinity-purified
recombinant human VEGF-C
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human VEGF-C (Catalog # 2179-VC)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: VEGF-C

Vascular endothelial growth factor C (VEGF-C) and VEGF-D constitute a VEGF sub-family that share the conserved VEGF homology domain (VHD) with other VEGF family members but are distinguished by their preferential formation of non-covalent homodimers. Both VEGF-C and -D have long N- and C-terminal propeptide extensions. The VEGF-C propeptide undergoes stepwise proteolytic processing to generate ligands with increasing affinity for VEGF-R3. However, only the fully processed VEGF-C containing just the VHD can bind VEGF-R2. None of the VEGF-C forms have appreciable affinity for VEGF-R1. VEGF-C is expressed in multiple adult human tissues, most prominently in lymph nodes, heart, placenta, ovary, and small intestine. Traces of VEGF-C are also detected in brain, liver, thymus, skeletal muscles, spleen, prostate, testis and colon. Unlike other VEGF family members, VEGF-C expression is not regulated by hypoxia. VEGF-C is a lymphangiogenic growth factor and the VEGF-C/VEGF-R3 signaling pathway has been shown to be crucial for lymphangiogenesis. VEGF-C and VEGF-R3 are usually co-expressed at sites with lymphatic vessel sprouting, in the embryo, and in various pathological conditions. VEGF-C stimulates lymphangiogenesis in the avian chorioallantoic membrane model. Over-expression of VEGF-C in breast cancer cells has been shown to increase intratumoral lymphangiogenesis, resulting in enhanced metastasis to regional lymph nodes and to the lungs. Mouse tumors expressing elevated levels of VEGF-C have increased lymphatic metastasis and increased lymphatic surface area in the tumor margin. VEGF-C is also associated with lymph node metastasis of colorectal carcinoma. Besides lymphangiogenesis, VEGF-C can have potent effects on physiological angiogenesis through its interaction with VEGF R2. The protein can stimulate migration and proliferation of endothelial cells in vitro and in vivo and has been shown to stimulate angiogenesis in the mouse cornea and in rabbit hind limb ischaemia (1 - 10).

  1. Joukov, V. et al. (1996) EMBO J. 15:290.
  2. Joukov, V. et al. (1997) EMBO J. 16:3898.
  3. Lee, J. et al. (1996) Proc. Natl. Acad. Sci. USA 93:1988.
  4. Oh, S. et al. (1997) Dev. Biol. 188:96.
  5. Witzenbichler, B. et al. (1998) Am. J. Pathol. 153:381.
  6. Cao, Y. et al. (1998) Proc. Natl. Acad. Sci. 95:14389.
  7. Stacker, S and M. Achen (1999) Growth Factors 17:1.
  8. Akagi, K. et al. (2000) Br. J. Cancer 83:887.
  9. Skobe, M. et al. (2001) Nature Medicine 2:192.
  10. Padera, T.P. et al. (2002) Science 296:1883.
Long Name
Vascular Endothelial Growth Factor C
Entrez Gene IDs
7424 (Human); 22341 (Mouse)
Alternate Names
Flt4 ligand; Flt4-L; vascular endothelial growth factor C; Vascular endothelial growth factor-related protein; VEGFC; VEGF-C; VRPFLT4 ligand DHM

Product Datasheets

You must select a language.


Citations for Human VEGF-C Biotinylated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
Filter your results:

Filter by:

  1. Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.
    Authors: Le Guen L, Karpanen T, Schulte D, Harris N, Koltowska K, Roukens G, Bower N, van Impel A, Stacker S, Achen M, Schulte-Merker S, Hogan B
    Development, 2014;141(6):1239-49.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  2. Regulation of lymphatic capillary regeneration by interstitial flow in skin.
    Authors: Goldman J, Conley KA, Raehl A, Bondy DM, Pytowski B, Swartz MA, Rutkowski JM, Jaroch DB, Ongstad EL
    Am. J. Physiol. Heart Circ. Physiol., 2006;292(5):H2176-83.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr


No product specific FAQs exist for this product, however you may

View all Antibody FAQs

Reviews for Human VEGF-C Biotinylated Antibody

There are currently no reviews for this product. Be the first to review Human VEGF-C Biotinylated Antibody and earn rewards!

Have you used Human VEGF-C Biotinylated Antibody?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review