Human VIP R2 APC-conjugated Antibody

  • Species Reactivity
  • Specificity
    Detects human VIP R2 in direct ELISAs.
  • Source
    Monoclonal Mouse IgG1 Clone # 476031
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    NS0 mouse myeloma cell line transfected with human VIP R2
    Accession # P41587
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of VIP R2 in HEK293 Human Cell Line Transfected with Human VIP R2 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with human VIP R2 and eGFP were stained with either (A) Mouse Anti-Human VIP R2 APC‑conjugated Monoclonal Antibody (Catalog # FAB5416A) or (B) Mouse IgG1 Allophycocyanin Isotype Control (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: VIP R2

Human VIP R2 (Vasoactive Intestinal Polypeptide Receptor 2), also known as VPAC2 is a 60-70 kDa seven transmembrane glycoprotein receptor that belongs to the G protein coupled receptor 2 family of proteins. The mature chain contains in its first extracellular region a hormone receptor domain (aa 49‑114) which includes three N-linked glycosylation sites and a "cilia targeting signal" comprised of and Arg-Asp-Tyr-Arg sequence. Human VIP R2 shares 85% aa sequence identity with mouse and rat VIP R2. In the extracellular domains, human VIP R2 shares 88% and 31% aa sequence identity with mouse VIP R2 and human VIP R1, respectively. VIP R2 is expressed predominantly in skeletal muscle, CD4+ T cells, smooth muscle cells, plasmacytoid dendritic cells, hepatic progenitor cells, monocytes, synoviocytes and select neurons. VIP R1 and VIP R2 bind VIP with equal affinity, but the two receptors are not redundant. VIP R1 interacts with RAMPs; VIP R2 does not. In the dentate gyrus, VIP R1 drives stem cells into a granule cell phenotype while VIP R2 maintains a Nestin+ phenotype.

  • Long Name:
    Vasoactive Intestinal Peptide Receptor 2
  • Entrez Gene IDs:
    7434 (Human); 22355 (Mouse); 29555 (Rat)
  • Alternate Names:
    FLJ16511; Helodermin-preferring VIP receptor; PACAP type III receptor; PACAPR3; PACAP-R3; PACAP-R-3; Pituitary adenylate cyclase-activating polypeptide type III receptor; vasoactive intestinal peptide receptor 2; vasoactive intestinal polypeptide receptor 2; VIP2R; VIPR2; VIP-R-2; VPAC2; VPCAP2R
Related Research Areas
Isotype Controls
Description Application Cat# Citations Images  

Mouse IgG1 APC-conjugated Antibody

Ctrl IC002A 5  
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Staining Reagents
Description Application Cat# Citations Images  

Flow Cytometry Staining Buffer (1X)

Flow FC001 3
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 1
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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