Human VIP R2 APC-conjugated Antibody Summary
Accession # P41587
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of VIP R2 in HEK293 Human Cell Line Transfected with Human VIP R2 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with human VIP R2 and eGFP were stained with either (A) Mouse Anti-Human VIP R2 APC‑conjugated Monoclonal Antibody (Catalog # FAB5416A) or (B) Mouse IgG1 Allophycocyanin Isotype Control (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: VIP R2
Human VIP R2 (Vasoactive Intestinal Polypeptide Receptor 2), also known as VPAC2 is a 60-70 kDa seven transmembrane glycoprotein receptor that belongs to the G protein coupled receptor 2 family of proteins. The mature chain contains in its first extracellular region a hormone receptor domain (aa 49‑114) which includes three N-linked glycosylation sites and a "cilia targeting signal" comprised of and Arg-Asp-Tyr-Arg sequence. Human VIP R2 shares 85% aa sequence identity with mouse and rat VIP R2. In the extracellular domains, human VIP R2 shares 88% and 31% aa sequence identity with mouse VIP R2 and human VIP R1, respectively. VIP R2 is expressed predominantly in skeletal muscle, CD4+ T cells, smooth muscle cells, plasmacytoid dendritic cells, hepatic progenitor cells, monocytes, synoviocytes and select neurons. VIP R1 and VIP R2 bind VIP with equal affinity, but the two receptors are not redundant. VIP R1 interacts with RAMPs; VIP R2 does not. In the dentate gyrus, VIP R1 drives stem cells into a granule cell phenotype while VIP R2 maintains a Nestin+ phenotype.
No product specific FAQs exist for this product, however you mayView all Antibody FAQs
Reviews for Human VIP R2 APC-conjugated Antibody
There are currently no reviews for this product. Be the first to review Human VIP R2 APC-conjugated Antibody and earn rewards!
Have you used Human VIP R2 APC-conjugated Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image