Hyaluronan (High MW)

Catalog # Availability Size / Price Qty
Product Details
Citations (9)
Reviews (1)

Hyaluronan (High MW) Summary


S. pyogenes
Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

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Citations for Hyaluronan (High MW)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

9 Citations: Showing 1 - 9
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  1. 4-methylumbelliferone inhibits clonogenic potency by suppressing high molecular weight-hyaluronan in fibrosarcoma cells
    Authors: K Hasegawa, R Saga, R Takahashi, R Fukui, M Chiba, K Okumura, E Tsuruga, Y Hosokawa
    Oncol Lett, 2020;19(4):2801-2808.  2020
  2. The material properties of naked mole-rat hyaluronan
    Authors: Y Kulaberogl, B Bhushan, F Hadi, S Chakrabart, WT Khaled, KS Rankin, ESJ Smith, D Frankel
    Sci Rep, 2019;9(1):6632.  2019
  3. Modulation of hyaluronan polymer size regulates proliferation of perimysial fibroblasts in thyroid eye disease
    Authors: R Ma, Q Li, Z Wang, Y Yuan, L Gan, J Qian
    Biochem. Biophys. Res. Commun., 2018;0(0):.  2018
  4. Role of CD44 in Regulating TLR2 Activation of Human Macrophages and Downstream Expression of Proinflammatory Cytokines
    Authors: M Qadri, S Almadani, GD Jay, KA Elsaid
    J. Immunol., 2017;0(0):.  2017
  5. Type III TGFbeta receptor and Src direct hyaluronan-mediated invasive cell motility.
    Authors: Allison P, Espiritu D, Barnett J, Camenisch T
    Cell Signal, 2015;27(3):453-9.  2015
  6. Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS.
    Authors: Mueller A, Yoon B, Sadiq S
    J Biol Chem, 2014;289(33):22888-99.  2014
  7. Crucial role of hyaluronan in neointimal formation after vascular injury.
    Authors: Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U
    PLoS ONE, 2013;8(3):e58760.  2013
  8. Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin.
    Authors: Martchenko M, Jeong SY, Cohen SN
    Proc. Natl. Acad. Sci. U.S.A., 2010;107(35):15583-8.  2010
  9. Identification of a novel chondroitin hydrolase in Caenorhabditis elegans.
    Authors: Kaneiwa T, Yamada S, Mizumoto S, Montano AM, Mitani S, Sugahara K
    J. Biol. Chem., 2008;283(22):14971-9.  2008


  1. Does R&D Systems® hyaluronan contain any chondroitin sulfate?

    • No, the hyaluronan is produced by microbial fermentation of Streptococcus pyogenes, which does not make chondroitin sulfate.

  2. What is the highest concentration that Catalog #GLR002, Hyaluronan (High MW), can be reconstituted to?

    • Hyaluronan (High MW) wil take some time to go into solution as it is a high MW polymer. A 1% solution can go into solution after about 24 hours of gentle rocking at room temperature followed by light vortexing if needed. More concentrated solutions may take longer to prepare. A 6% solution may take up to one week to fully solubilize.

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Reviews for Hyaluronan (High MW)

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Hyaluronan (High MW)
By Timothy Audam on 10/20/2020

LPS free HA for a confident experiment--particularly when treating immune cells.