Hyaluronidase 1/HYAL1 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-83409

Novus Biologicals
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Hyaluronidase 1/HYAL1 Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHF

Reactivity Notes

Reactivity reported in scientific literature (PMID: 23560496)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Hyaluronidase 1/HYAL1 Antibody - BSA Free

Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409]

Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409]

Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409] - Staining of human liver shows moderate to strong granular cytoplasmic positivity in hepatocytes.
Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409]

Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409]

Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409] - Staining of human kidney shows moderate to strong granular cytoplasmic positivity in cells in tubules.
Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409]

Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409]

Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409] - Staining of human gallbladder shows moderate to strong granular cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409]

Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409]

Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409] - Staining of human tonsil shows very weak positivity as expected.
Hyaluronidase 1/HYAL1 Antibody

Immunohistochemistry: Hyaluronidase 1/HYAL1 Antibody [NBP1-83409] -

Immunohistochemistry of candidate biomarkers in prostate cancer. Representative immunohistochemical staining of ACPP, ADAM9, ALDH1A2, CASR, CCND1, CCPG1, CD34, CD44, CD44v6, CHGA, CHMP1A, EI24, ENO2, GADD45B, HA, HAS2, HES6, HMMR, HOXC6, HYAL1, IGF1, IQCK, MAP4K4, MKI67, PAGE4, PLIN2, PTEN, SIAH2, SMAD4, SOX9, SPP1, SYP, & TP53 from prostate cancer tissue microarrays. Scale bar represents 50 μm. Image collected & cropped by CiteAb from the following publication (https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-244), licensed under a CC-BY license. Not internally tested by Novus Biologicals.
Hyaluronidase 1/HYAL1 Antibody - BSA Free Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody - BSA Free [NBP1-83409]

Immunohistochemistry-Paraffin: Hyaluronidase 1/HYAL1 Antibody - BSA Free [NBP1-83409]

Analysis in human liver and tonsil tissues using NBP1-83409 antibody. Corresponding HYAL1 RNA-seq data are presented for the same tissues.

Applications for Hyaluronidase 1/HYAL1 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Hyaluronidase 1/HYAL1

HYAL1 codes for a protein that may have a role in promoting tumor progression and blocking the TGFB1-enhanced cell growth, and is expressed highly in the liver, kidney, and heart, with weaker expression in the lung placenta, and skeletal muscle. There are seven isoforms of HYAL1, with the longest being isoform 1, which is only expressed in bladder and prostate cancer cells and is 435 amino acids long and weighs approximately 48 kDa. Current studies are being done on several diseases and disorders relating to this gene including lung carcinoma, lysosomal storage disease, diabetes mellitus, ovarian cancer, endometrial carcinoma, prostate cancer, and breast cancer. HYAL1 has also been shown to have interactions with GUSB, ARSB, IDUA, FAM107B, and COL2A1 in pathways such as the metabolic, lysosome, and Maroteaux-Lamy syndrome pathways.

Long Name

Hyaluronoglucosaminidase-1

Alternate Names

FUS2, HYAL1, Hyaluronoglucosaminidase 1, LUCA1, NAT6

Gene Symbol

HYAL1

Additional Hyaluronidase 1/HYAL1 Products

Product Documents for Hyaluronidase 1/HYAL1 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Hyaluronidase 1/HYAL1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Hyaluronidase 1/HYAL1 Antibody - BSA Free

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Protocols

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