Catalog Number: 1520
Chemical Name: 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
Biological Activity
Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC50 = 7.5 μM) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol with gentle warming and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Hypericin in cancer treatment: more light on the way.
    Agostinis et al.
    Int.J.Biochem.Cell Biol., 2002;34:221
  2. Inhibition of c-erbB-2 expression and activity in human ovarian carcinoma cells by hypericin.
    Hwang et al.
    Anticancer Res., 2001;21:2649
  3. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation.
    Lenard et al.
    Proc.Natl.Acad.Sci.U.S.A., 1993;90:158
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