Chemical Name: 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
Biological ActivityPhotosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC50 = 7.5 μM) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Hypericin in cancer treatment: more light on the way.
Agostinis et al.
Int.J.Biochem.Cell Biol., 2002;34:221
Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation.
Lenard et al.
Inhibition of c-erbB-2 expression and activity in human ovarian carcinoma cells by hypericin.
Hwang et al.
Anticancer Res., 2001;21:2649
Citation for Hypericin
The citations listed below are publications that use Tocris products. Selected citations for Hypericin include:
1 Citation: Showing 1 - 1
Concomitant SK current activation and sodium current inhibition cause J wave syndrome.
Authors: Chen Et al.
JCI Insight 2018;3
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