Catalog Number: 0833
Chemical Name: N-[1-(4-Carboxamidobutyl)-1H-pyrazol-3-yl)]-N'-(2,2,2-trifluoroethyl)guanidine
Biological Activity
A potent histamine H2 receptor antagonist.
Technical Data
  • M.Wt:
    306.29
  • Formula:
    C11H17F3N6O
  • Solubility:
    Soluble in ethanol and to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    84545-30-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model.
    Gompertz et al.
    Agents Actions, 1991;33:161
  2. Morphological stomach findings in rats and mice treated with the H2 receptor antagonists, ICI 125,211 and ICI 162,846.
    Streett et al.
    Toxicol.Pathol., 1988;16:299
  3. Inhibition of human gastric secretion by ICI 162,846 - a new histamine H2 receptor antagonist.
    Wilson et al.
    Br.J.Clin.Pharmacol., 1986;21:685

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