Catalog Number: 0820
Biological Activity
Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.
Technical Data
  • M.Wt:
    691.87
  • Formula:
    C38H53N5O7
  • Sequence:
    YXXFL

    (Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib)

  • Solubility:
    Soluble to 69.19 mg/ml in DMSO and to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    89352-67-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217.
    Cohen et al.
    J.Pharmacol.Exp.Ther., 1996;238:769
  2. ICI-174,864: a highly selective antagonist for the opioid δ receptor.
    Cotton et al.
    Eur.J.Pharmacol., 1984;97:331
  3. Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin.
    Cowan et al.
    Neuropeptides, 1985;5:311
  4. Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO).
    Hirning et al.
    Neuropeptides, 1985;5:383
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ICI 174,864 include:

3 Citations: Showing 1 - 3
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  1. Opioid and progesterone signaling is obligatory for early human embryogenesis.
    Authors: Gallego Et al.
    J Neurophysiol 2009;18:737
  2. N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface.
    Authors: Markkanen and Petäjä-Repo
    J Biol Chem 2008;283:29086
  3. Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists.
    Authors: Neilan Et al.
    Br J Pharmacol 1999;128:556

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