Biological ActivityICI 174,864 is a selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.
(Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib)
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Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217.
Cohen et al.
ICI-174,864: a highly selective antagonist for the opioid δ receptor.
Cotton et al.
Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin.
Cowan et al.
Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO).
Hirning et al.
Citations for ICI 174,864
The citations listed below are publications that use Tocris products. Selected citations for ICI 174,864 include:
5 Citations: Showing 1 - 5
Synapse-specific opioid modulation of thalamo-cortico-striatal circuits.
Authors: Birdsong Et al.
Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.
Authors: Leroy Et al.
Opioid and progesterone signaling is obligatory for early human embryogenesis.
Authors: Gallego Et al.
J Neurophysiol 2009;18:737
N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface.
Authors: Markkanen and Petäjä-Repo
J Biol Chem 2008;283:29086
Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists.
Authors: Neilan Et al.
Br J Pharmacol 1999;128:556
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