ICOS Antibody (RM417)

Novus Biologicals | Catalog # NBP2-89090

Recombinant Monoclonal Antibody
Novus Biologicals
100% Guarantee

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM417 expressed in HEK293
View all ICOS Primary Antibodies »

Product Specifications

Immunogen

A peptide corresponding to the C-terminus of human ICOS

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ICOS Antibody (RM417)

Immunohistochemistry-Paraffin: ICOS Antibody (RM417) [NBP2-89090]

Immunohistochemistry-Paraffin: ICOS Antibody (RM417) [NBP2-89090]

Immunohistochemistry-Paraffin: ICOS Antibody (RM417) [NBP2-89090] - Immunohistochemical staining of formalin fixed and paraffin embedded human appendix tissue section using anti-CD278 rabbit monoclonal antibody (Clone RM417) at a 1:100 dilution.
Immunohistochemistry-Paraffin: ICOS Antibody (RM417) [NBP2-89090]

Immunohistochemistry-Paraffin: ICOS Antibody (RM417) [NBP2-89090]

Immunohistochemistry-Paraffin: ICOS Antibody (RM417) [NBP2-89090] - Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using anti-CD278 rabbit monoclonal antibody (Clone RM417) at a 1:100 dilution.

Applications for ICOS Antibody (RM417)

Application
Recommended Usage

Immunohistochemistry

1:100 - 1:200

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: ICOS

The C398.4A antibody reacts with the human, mouse and rat 47-57 kD ICOS protein, also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation.

Long Name

Inducible Co-stimulator

Alternate Names

AILIM, CD278, CRP-1

Gene Symbol

ICOS

Additional ICOS Products

Product Documents for ICOS Antibody (RM417)

Certificate of Analysis

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Product Specific Notices for ICOS Antibody (RM417)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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