Group 2 ILCs
Group 2 innate lymphoid cells (ILC2s) are a subset of innate lymphoid cells (ILCs) along with ILC1s and ILC3s. ILC2s are an innate counterpart to Th2 cells due to their shared cytokines and transcription factors. ILC2s trigger Type 2 inflammation and tissue repair in response to allergens and parasitic infections, such as helminths. These cells do not have an antigen-specific response due to a lack of T cell receptor (TCR) or B cell receptor (BCR). Prior research has specified two distinct ILC2 subsets: natural ILC2 (nILC2) and inflammatory ILC2 (iILC2). These subsets are primarily activated by IL-33 and IL-25, respectively; however, ILC2s are also activated by IL-4, TSLP, and prostaglandin D2 (PGD2). Following infection, ILC2s secrete Amphiregulin, IL-4, IL-5, IL-9, and IL-13.
ILC2 Cytokine Receptors
ILC2 Inducing Cytokines
ILC2 Secreted Cytokines
ILC2 Transcription Factors
Other ILC2 Surface Markers