Key Product Details

Species Reactivity

Mouse

Applications

Western Blot

Label

Janelia Fluor 525

Antibody Source

Monoclonal Rat IgG1 Clone # 694204
View all IL-1ra/IL-1F3 Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant mouse IL-1ra/IL-1F3
Arg8-Gln159
Accession # Q542W1

Specificity

Detects mouse IL-1ra/IL-1F3 in direct ELISAs and Western blots. In Western blots, approximately 30%-50% cross-reactivity with recombinant equine IL-1ra and recombinant human (rh) IL-1ra is observed. Less than 5% cross-reactivity with recombinant mouse (rm) IL-1b, rmIL-18, rmIL-36Ra, rmIL-36a, rmIL-36b, rmIL-1F10, rhIL-36, rhIL-1F7, or recombinant porcine IL-1ra, or recombinant rat IL-1ra is observed.

Clonality

Monoclonal

Host

Rat

Isotype

IgG1

Applications for IL-1ra/IL-1F3/IL1RN Antibody (694204) [Janelia Fluor® 525]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: IL-1ra/IL-1F3

IL-1ra (IL-1 receptor antagonist) is a widely expressed acute phase protein that serves to dampen inflammation. IL-1ra binds to both IL-1 RI and IL-1 RII. It competitively inhibits IL-1 (alpha or beta) binding to IL-1 RI and does not trigger recruitment of the accessory molecule IL-1 R AcP or activation of IL-1 RI signaling. IL-1ra blocks the proinflammatory actions of IL-1 including Prostaglandin E2 and IL-6 release from endothelial cells, fever generation, thrombocytosis, the production of hepatic acute phase proteins, and neutrophil expansion and infiltration.

Long Name

Interleukin 1 Receptor Antagonist

Alternate Names

DIRA, ICIL-1ra, IL-1F3, IL-1ra3, IL-1RN, IL1ra, IL1RN, MVCD4

Gene Symbol

IL1RN

Additional IL-1ra/IL-1F3 Products

Product Documents for IL-1ra/IL-1F3/IL1RN Antibody (694204) [Janelia Fluor® 525]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for IL-1ra/IL-1F3/IL1RN Antibody (694204) [Janelia Fluor® 525]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

No product specific FAQs exist for this product.

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Associated Pathways

IL-1 Family Signaling Pathways IL-1 Family Signaling Pathway Thumbnail