Chemical Name: N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide hydrochloride
Biological ActivityHec1 inhibitor. Binds Hec1, inhibiting its association with Nek2 and kinetochores. Causes arrest of mitosis and inhibits proliferation in breast cancer cell lines (GI50= 10 - 20 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.
Wu G, Qiu XL, Zhou L et al.
Citation for INH1
The citations listed below are publications that use Tocris products. Selected citations for INH1 include:
1 Citation: Showing 1 - 1
An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma.
Authors: Linton Et al.
Br J Cancer 2014;110:510
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