Catalog Number: 3551
Chemical Name: N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide hydrochloride
Biological Activity
Hec1 inhibitor. Binds Hec1, inhibiting its association with Nek2 and kinetochores. Causes arrest of mitosis and inhibits proliferation in breast cancer cell lines (GI50= 10 - 20 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.
    Wu G, Qiu XL, Zhou L et al.
    Cancer Res

The citations listed below are publications that use Tocris products. Selected citations for INH1 include:

Showing Results 1 - 1 of 1

  1. An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma.
    Authors: Linton Et al.
    Br J Cancer
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