Potent and selective melanocortin MC4
receptor antagonist (IC50
values are 0.5 and 44.9 nM at MC4
respectively) that antagonizes the effects of α
-MSH. Suppresses thyrotropin-releasing hormone (TRH) release, attenuates food intake and reduces formalin-induced pain in vivo
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All Tocris products are intended for laboratory research use only.
Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors.
Kim et al.
Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test.
Bellasio et al.
Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake.
Verty et al.