Catalog Number: 2575
Chemical Name: N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-isoleucyl-L-leucine
Biological Activity
Inhibitor of the major neurotensin and neuromedin N degrading enzymes (IC50 values are 31, 40, 52 and 58 nM for endopeptidase 24.15, endopeptidase 24.11, leucine aminopeptidase and endopeptidase 24.16 respectively). Exhibits analgesic effects in various nociception assays.
Technical Data
  • M.Wt:
    449.54
  • Formula:
    C23H35N3O6
  • Sequence:
    XIL (Modifications: X-1 = N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl])
  • Solubility:
    Soluble to 0.80 mg/ml in sodium bicarbonate (0.01M)
  • Storage:
    Store at -20°C
  • CAS No:
    148473-36-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes.
    Doulut et al.
    J.Med.Chem., 1993;36:1369
  2. Effects of thiorphan, bestatin and a novel metallopeptidase inhibitor JMV 390-1 on the recovery of neurotensin and neuromedin N released from mouse hypothalamus.
    Kitabgi et al.
    Neurosci.Lett., 1992;142:200
  3. The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors.
    Menard et al.
    Biochem.J., 1996;320:687

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