JNJ 10181457 dihydrochloride

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Cat.No. 4019 - JNJ 10181457 dihydrochloride | C20H28N2O.2HCl | CAS No. 544707-20-2
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Description: H3 antagonist

Chemical Name: 4-[3-[4-[Piperidinyl]but-1-ynyl]benzyl]morpholine dihydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Histamine H3 receptor antagonist (pKi values are 8.15 and 8.93 for rat and human H3 receptors respectively). Increases extracellular norepinephrine and acetylcholine levels in rat frontal cortex but does not stimulate dopamine release. Brain penetrant.

Technical Data

M.Wt:
385.37
Formula:
C20H28N2O.2HCl
Solubility:
Soluble to 100 mM in water and to 25 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
544707-20-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

Product Datasheets

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Citation for JNJ 10181457 dihydrochloride

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