JNJ 10181457 dihydrochloride

Name: JNJ 10181457 dihydrochloride
Brand: Tocris Bioscience
SKU: 4019

Catalog #: 4019
1 Citation Datasheet / COA / SDS

Discontinued Product

4019 has been discontinued.

View all Histamine H3 Receptor Antagonists products.

JNJ 10181457 dihydrochloride | CAS No. 544707-20-2 | Histamine H3 Receptor Antagonists

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Description: H3 antagonist

Chemical Name: 4-[3-[4-[Piperidinyl]but-1-ynyl]benzyl]morpholine dihydrochloride

Purity: ≥98%

View All Products for Histamine H3 Receptor Antagonists

Product Details

Citations (1)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Histamine H₃ receptor antagonist (pK_i values are 8.15 and 8.93 for rat and human H₃ receptors respectively). Increases extracellular norepinephrine and acetylcholine levels in rat frontal cortex but does not stimulate dopamine release. Brain penetrant.

Technical Data

M.Wt:

385.37

Formula:

C₂₀H₂₈N₂O.2HCl

Solubility:

Soluble to 100 mM in water and to 25 mM in ethanol

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

544707-20-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

Background References

JNJ10181457, a histamine H3 receptor inverse agonist, regulates inï¿½vivo microglial functions and improves depression-like behaviours in mice
T Iida, T Yoshikawa, A Kárpáti, T Matsuzawa, H Kitano, A Mogi, R Harada, F Naganuma, T Nakamura, K Yanai
Biochem. Biophys. Res. Commun., 2017;0(0):.
Histamine H₃ receptor antagonists: from target identification to drug leads.
Bonaventure et al.
Biochem.Pharmacol., 2007;73:1084
The histamine H₃ receptor: an attractive target for the treatment of cognitive disorders.
Esbenshade et al.
Br.J.Pharmacol., 2008;154:1166
JNJ-10181457, a selective non-imidazole histamine H₃ receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition.
Boggs et al.
Neuropharmacology, 2009;56:1131

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for JNJ 10181457 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for JNJ 10181457 dihydrochloride include:

1 Citation: Showing 1 - 1

JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice.
Authors: Iida
Biochem Biophys Res Commun 2017;488(3):534

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