JNJ 10181457 dihydrochloride
Chemical Name: 4-[3-[4-[Piperidinyl]but-1-ynyl]benzyl]morpholine dihydrochloride
Biological ActivityHistamine H3 receptor antagonist (pKi values are 8.15 and 8.93 for rat and human H3 receptors respectively). Increases extracellular norepinephrine and acetylcholine levels in rat frontal cortex but does not stimulate dopamine release. Brain penetrant.
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Histamine H3 receptor antagonists: from target identification to drug leads.
Bonaventure et al.
The histamine H3 receptor: an attractive target for the treatment of cognitive disorders.
Esbenshade et al.
JNJ-10181457, a selective non-imidazole histamine H3 receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition.
Boggs et al.
Citation for JNJ 10181457 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for JNJ 10181457 dihydrochloride include:
1 Citation: Showing 1 - 1
JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice.
Biochem Biophys Res Commun 2017;488(3):534
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