JNJ 47965567

Catalog # Availability Size / Price Qty
JNJ 47965567 | CAS No. 1428327-31-4 | P2X Receptor Antagonists
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Description: Potent and selective P2X7 antagonist; brain penetrant

Chemical Name: 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews (3)

Biological Activity

Potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP-induced IL-1β release from monocytes in vitro and from rat brain in vivo. Attenuates amphetamine-induced hyperactivity in rats. Brain penetrant.

Technical Data

Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for JNJ 47965567

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Reviews for JNJ 47965567

Average Rating: 4.3 (Based on 3 Reviews)

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Good inhibitor
By Stefan Uderhardt on 06/06/2020
Application: Species: Mouse

DMSO dilution 100 μM

In vivo usage
By Spandita Dutta on 08/07/2018
Application: Species: Mouse

I have used this product emulsified in 30% sulphoxymethylester, and injected them sub-cutaneously to study IL-1beta release mechanism in the hippocampus of the brain. I am currently working on its effect on hippocampal neurons in culture.

P2X7 blocker
By Anonymous on 01/31/2018
Application: Species: Mouse

Used to block a potentially P2X7-dependent process, but no effect was observed. No positive control so unsure if the drug actually blocked its target. More experiments needed.

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