Potent and selective P2X7
values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP
release from monocytes in vitro
and from rat brain in vivo
. Attenuates amphetamine
-induced hyperactivity in rats. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.
Bhattacharya et al.
Synthesis and pharmacological characterization of two novel, brain penetrating P2X7 antagonists.
Letavic et al.
ACS Med.Chem.Lett., 2013;12:419