JNJ 47965567

Catalog # Availability Size / Price Qty
5299/10
5299/50
JNJ 47965567 | CAS No. 1428327-31-4 | P2X Receptor Antagonists
1 Image
Description: Potent and selective P2X7 antagonist; brain penetrant

Chemical Name: 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews (3)

Biological Activity

Potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP-induced IL-1β release from monocytes in vitro and from rat brain in vivo. Attenuates amphetamine-induced hyperactivity in rats. Brain penetrant.

Technical Data

M.Wt:
488.64
Formula:
C28H32N4O2S
Solubility:
Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1428327-31-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for JNJ 47965567

The citations listed below are publications that use Tocris products. Selected citations for JNJ 47965567 include:

1 Citation: Showing 1 - 1

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for JNJ 47965567

Average Rating: 4.3 (Based on 3 Reviews)

5 Star
66.67%
4 Star
0%
3 Star
33.33%
2 Star
0%
1 Star
0%

Have you used JNJ 47965567?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Good inhibitor
By Stefan Uderhardt on 06/06/2020
Application: Species: Mouse

DMSO dilution 100 μM


In vivo usage
By Spandita Dutta on 08/07/2018
Application: Species: Mouse

I have used this product emulsified in 30% sulphoxymethylester, and injected them sub-cutaneously to study IL-1beta release mechanism in the hippocampus of the brain. I am currently working on its effect on hippocampal neurons in culture.


P2X7 blocker
By Anonymous on 01/31/2018
Application: Species: Mouse

Used to block a potentially P2X7-dependent process, but no effect was observed. No positive control so unsure if the drug actually blocked its target. More experiments needed.


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.