Chemical Name: 7-[4,6-Bis(1,1-dimethylethyl)-2-pyrimidinyl]-5,6,7,8-tetrahydro-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazolo[4,3-a]pyrazine
Biological ActivityPotent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor (IC50 = 20 - 40 nM). Displays >7000-fold selectivity for human MOGAT2 over human DGAT2. Modulates intestinal lipid absorption in mice. Decreases triglyceride, diacylglycerol and fatty acid synthesis in mouse model of fatty liver. Chronic treatment decreases hepatic triglyceride content and body weight, and improves glucose tolerance in diet-induced obese mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity.
Okuma et al.
JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis.
Okuma et al.
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