JW 55

Catalog # Availability Size / Price Qty
4514/10
4514/50
JW 55 | CAS No. 664993-53-7 | Tankyrase Inhibitors
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Description: Tankyrase inhibitor

Chemical Name: N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of JW55 is reviewed on the chemical probes website.

Technical Data

M.Wt:
434.48
Formula:
C25H26N2O5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
664993-53-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for JW 55

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2 Citations: Showing 1 - 2

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