JWH 133

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JWH 133 | CAS No. 259869-55-1 | Cannabinoid R2/CB2 Agonists
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Description: Potent and selective CB2 agonist

Chemical Name: (6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran

Purity: ≥98%

Product Details
Citations (37)
Supplemental Products
Reviews (1)

Biological Activity

JWH 133 is a potent CB2 selective agonist (Ki = 3.4 nM). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis. Activity also enhances the release of IL-10 by LPS/IFN-γ-stimulated macrophages and results in downregulation of the IL-12 subunit p40.

Technical Data

Soluble to 100 mM in ethanol and to 20 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for JWH 133

The citations listed below are publications that use Tocris products. Selected citations for JWH 133 include:

37 Citations: Showing 1 - 10

  1. Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2.
    Authors: Acevedo-Canabal Et al.
    Cannabis Cannabinoid Res  2019;4:88
  2. Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.
    Authors: Sheng Et al.
    Pain Res Manag  2019;2019:1260353
  3. On the influence of cannabinoids on cell morphology and motility of glioblastoma cells.
    Authors: Hohmann Et al.
    PLoS One  2019;14:e0212037
  4. TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro.
    Authors: Balleza-Tapia Et al.
    Elife  2018;7
  5. Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma.
    Authors: Khan Et al.
    BMC Cancer  2018;18:583
  6. Activation of cannabinoid receptor type 2 by JWH133 alleviates bleomycin-induced pulmonary fibrosis in mice.
    Authors: Fu
    Oncotarget  2017;8(61):103486
  7. Overactive type 2 cannabinoid receptor induces meiosis in fetal gonads and impairs ovarian reserve.
    Authors: De Domenico
    Cell Death Dis  2017;8(10):e3085
  8. CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells.
    Authors: Hytti
    Sci Rep  2017;7(1):16169
  9. Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca2+ oscillations in mouse pancreatic acinar cells
    Authors: Huang Et al.
    Scientific Reports  2016;6:29757
  10. Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands.
    Authors: Kruk-Slomka Et al.
    Neural Plast  2016;2016:9815092
  11. Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain.
    Authors: Rivera Et al.
    Front Cell Neurosci  2015;9:379
  12. Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream.
    Authors: Zhou Et al.
    Pharmacol Res Perspect  2015;64:32
  13. Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
    Authors: Presley Et al.
    Eur Heart J  2015;3:e00159
  14. Cannabinoids receptor type 2, CB2, expression correlates with human colon cancer progression and predicts patient survival.
    Authors: Martínez-Martínez Et al.
    Oncoscience  2015;2:131
  15. A cannabigerol derivative suppresses immune responses and protects mice from experimental autoimmune encephalomyelitis.
    Authors: Carrillo-Salinas Et al.
    PLoS One  2014;9:e94733
  16. △(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.
    Authors: Williams Et al.
    J Biol Chem  2014;9:369
  17. Cannabinoid receptor type-2 stimulation, blockade, and deletion alters the vascular inflammatory responses to traumatic brain injury.
    Authors: Amenta Et al.
    J Neuroimmune Pharmacol  2014;11:191
  18. The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties.
    Authors: Rossi Et al.
    PLoS One  2013;8:e80022
  19. CB1 cannabinoid receptors couple to focal adhesion kinase to control Ins release.
    Authors: Malenczyk Et al.
    J Biol Chem  2013;288:32685
  20. Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice.
    Authors: Fraga-Silva Et al.
    Clin Dev Immunol  2013;2013:263846
  21. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
    Authors: Marini Et al.
    Br J Pharmacol  2013;169:887
  22. The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques.
    Authors: Montecucco Et al.
    FASEB J  2012;33:846
  23. Cannabinoid receptor CB2 protects against balloon-induced neointima formation.
    Authors: Molica Et al.
    Am J Physiol Heart Circ Physiol  2012;302:H1064
  24. Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors.
    Authors: García-Gutiérrez Et al.
    Br J Pharmacol  2012;165:951
  25. Cannabinoid CB? receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice.
    Authors: Navarrete Et al.
    Br J Pharmacol  2012;165:260
  26. Effect of cannabinoid receptor activation on spreading depression.
    Authors: Kazemi Et al.
    Iran J Basic Med Sci  2012;15:926
  27. CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3β/β-catenin signaling.
    Authors: Trazzi Et al.
    Br J Pharmacol  2010;285:10098
  28. Small intestinal cannabinoid receptor changes following a single colonic insult with oil of mustard in mice.
    Authors: Kimball Et al.
    Front Pharmacol  2010;1:132
  29. Cannabinoid CB2 receptor potentiates obesity-associated inflammation, Ins resistance and hepatic steatosis.
    Authors: Deveaux Et al.
    J Neuroinflammation  2009;4:e5844
  30. The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy.
    Authors: Defer Et al.
    PLoS One  2009;23:2120
  31. CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways.
    Authors: Montecucco Et al.
    Am J Physiol Heart Circ Physiol  2008;294:H1145
  32. CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration.
    Authors: Rajesh Et al.
    Br J Pharmacol  2008;153:347
  33. Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.
    Authors: Mukhopadhyay Et al.
    J Am Coll Cardiol  2007;50:528
  34. CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.
    Authors: Rajesh Et al.
    Am J Physiol Heart Circ Physiol  2007;293:H2210
  35. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism.
    Authors: Underdown Et al.
    Br J Pharmacol  2005;146:809
  36. Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling.
    Authors: Correa Et al.
    Br J Pharmacol  2005;145:441
  37. Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
    Authors: Mathison Et al.
    Br J Pharmacol  2004;142:1247


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