selective agonist (K
= 3.4 nM). Approx. 200-fold selective over CB
, reducing spasticity in a murine model of multiple sclerosis. Activity also enhances the release of IL-10 by LPS/IFN-
-stimulated macrophages and results in downregulation of the IL-12 subunit p40.
Water Soluble Emulsion also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products.
Selected citations for JWH 133 include:
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Activation of cannabinoid receptor type 2 by JWH133 alleviates bleomycin-induced pulmonary fibrosis in mice.
Overactive type 2 cannabinoid receptor induces meiosis in fetal gonads and impairs ovarian reserve.
Authors: De Domenico
Cell Death Dis 2017;8(10):e3085
CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells.
Sci Rep 2017;7(1):16169
Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca2+ oscillations in mouse pancreatic acinar cells
Authors: Huang Et al.
Scientific Reports 2016;6:29757
Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands.
Authors: Kruk-Slomka Et al.
Neural Plast 2016;2016:9815092
Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain.
Authors: Rivera Et al.
Front Cell Neurosci 2015;9:379
Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream.
Authors: Zhou Et al.
Pharmacol Res Perspect 2015;64:32
Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
Authors: Presley Et al.
Eur Heart J 2015;3:e00159
Cannabinoids receptor type 2, CB2, expression correlates with human colon cancer progression and predicts patient survival.
Authors: Martínez-Martínez Et al.
A cannabigerol derivative suppresses immune responses and protects mice from experimental autoimmune encephalomyelitis.
Authors: Carrillo-Salinas Et al.
PLoS One 2014;9:e94733
△(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.
Authors: Williams Et al.
J Biol Chem 2014;9:369
Cannabinoid receptor type-2 stimulation, blockade, and deletion alters the vascular inflammatory responses to traumatic brain injury.
Authors: Amenta Et al.
J Neuroimmune Pharmacol 2014;11:191
CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.
Authors: Malenczyk Et al.
J Biol Chem 2013;288:32685
Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice.
Authors: Fraga-Silva Et al.
Clin Dev Immunol 2013;2013:263846
Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
Authors: Marini Et al.
Br J Pharmacol 2013;169:887
The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques.
Authors: Montecucco Et al.
FASEB J 2012;33:846
Cannabinoid receptor CB2 protects against balloon-induced neointima formation.
Authors: Molica Et al.
Am J Physiol Heart Circ Physiol 2012;302:H1064
Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors.
Authors: García-Gutiérrez Et al.
Br J Pharmacol 2012;165:951
Cannabinoid CB? receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice.
Authors: Navarrete Et al.
Br J Pharmacol 2012;165:260
Effect of cannabinoid receptor activation on spreading depression.
Authors: Kazemi Et al.
Iran J Basic Med Sci 2012;15:926
CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3β/β-catenin signaling.
Authors: Trazzi Et al.
Br J Pharmacol 2010;285:10098
Small intestinal cannabinoid receptor changes following a single colonic insult with oil of mustard in mice.
Authors: Kimball Et al.
Front Pharmacol 2010;1:132
Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis.
Authors: Deveaux Et al.
J Neuroinflammation 2009;4:e5844
The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy.
Authors: Defer Et al.
PLoS One 2009;23:2120
CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways.
Authors: Montecucco Et al.
Am J Physiol Heart Circ Physiol 2008;294:H1145
CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration.
Authors: Rajesh Et al.
Br J Pharmacol 2008;153:347
Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.
Authors: Mukhopadhyay Et al.
J Am Coll Cardiol 2007;50:528
CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.
Authors: Rajesh Et al.
Am J Physiol Heart Circ Physiol 2007;293:H2210
Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism.
Authors: Underdown Et al.
Br J Pharmacol 2005;146:809
Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling.
Authors: Correa Et al.
Br J Pharmacol 2005;145:441
Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
Authors: Mathison Et al.
Br J Pharmacol 2004;142:1247
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