JWH 133

  ( 31 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1343
Chemical Name:(6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Product Details
Citations (31)
Supplemental Products
Reviews
Biological Activity
Potent CB2 selective agonist (Ki = 3.4 nM). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis. Activity also enhances the release of IL-10 by LPS/IFN-γ-stimulated macrophages and results in downregulation of the IL-12 subunit p40.

Water Soluble Emulsion also available.

Technical Data
  • M.Wt:
    312.49
  • Formula:
    C22H32O
  • Solubility:
    Soluble to 100 mM in ethanol and to 50 mM in DMSO with gentle warming
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    259869-55-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for JWH 133 include:

31 Citations: Showing 1 - 10
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  1. Activation of cannabinoid receptor type 2 by JWH133 alleviates bleomycin-induced pulmonary fibrosis in mice.
    Authors: Fu
    Oncotarget  2017;8(61):103486
  2. Overactive type 2 cannabinoid receptor induces meiosis in fetal gonads and impairs ovarian reserve.
    Authors: De Domenico
    Cell Death Dis  2017;8(10):e3085
  3. CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells.
    Authors: Hytti
    Sci Rep  2017;7(1):16169
  4. Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca2+ oscillations in mouse pancreatic acinar cells
    Authors: Huang Et al.
    Scientific Reports  2016;6:29757
  5. Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands.
    Authors: Kruk-Slomka Et al.
    Neural Plast  2016;2016:9815092
  6. Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain.
    Authors: Rivera Et al.
    Front Cell Neurosci  2015;9:379
  7. Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream.
    Authors: Zhou Et al.
    Pharmacol Res Perspect  2015;64:32
  8. Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
    Authors: Presley Et al.
    Eur Heart J  2015;3:e00159
  9. Cannabinoids receptor type 2, CB2, expression correlates with human colon cancer progression and predicts patient survival.
    Authors: Martínez-Martínez Et al.
    Oncoscience  2015;2:131
  10. A cannabigerol derivative suppresses immune responses and protects mice from experimental autoimmune encephalomyelitis.
    Authors: Carrillo-Salinas Et al.
    PLoS One  2014;9:e94733
  11. △(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.
    Authors: Williams Et al.
    J Biol Chem  2014;9:369
  12. Cannabinoid receptor type-2 stimulation, blockade, and deletion alters the vascular inflammatory responses to traumatic brain injury.
    Authors: Amenta Et al.
    J Neuroimmune Pharmacol  2014;11:191
  13. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.
    Authors: Malenczyk Et al.
    J Biol Chem  2013;288:32685
  14. Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice.
    Authors: Fraga-Silva Et al.
    Clin Dev Immunol  2013;2013:263846
  15. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
    Authors: Marini Et al.
    Br J Pharmacol  2013;169:887
  16. The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques.
    Authors: Montecucco Et al.
    FASEB J  2012;33:846
  17. Cannabinoid receptor CB2 protects against balloon-induced neointima formation.
    Authors: Molica Et al.
    Am J Physiol Heart Circ Physiol  2012;302:H1064
  18. Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors.
    Authors: García-Gutiérrez Et al.
    Br J Pharmacol  2012;165:951
  19. Cannabinoid CB? receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice.
    Authors: Navarrete Et al.
    Br J Pharmacol  2012;165:260
  20. Effect of cannabinoid receptor activation on spreading depression.
    Authors: Kazemi Et al.
    Iran J Basic Med Sci  2012;15:926
  21. CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3β/β-catenin signaling.
    Authors: Trazzi Et al.
    Br J Pharmacol  2010;285:10098
  22. Small intestinal cannabinoid receptor changes following a single colonic insult with oil of mustard in mice.
    Authors: Kimball Et al.
    Front Pharmacol  2010;1:132
  23. Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis.
    Authors: Deveaux Et al.
    J Neuroinflammation  2009;4:e5844
  24. The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy.
    Authors: Defer Et al.
    PLoS One  2009;23:2120
  25. CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways.
    Authors: Montecucco Et al.
    Am J Physiol Heart Circ Physiol  2008;294:H1145
  26. CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration.
    Authors: Rajesh Et al.
    Br J Pharmacol  2008;153:347
  27. Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.
    Authors: Mukhopadhyay Et al.
    J Am Coll Cardiol  2007;50:528
  28. CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.
    Authors: Rajesh Et al.
    Am J Physiol Heart Circ Physiol  2007;293:H2210
  29. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism.
    Authors: Underdown Et al.
    Br J Pharmacol  2005;146:809
  30. Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling.
    Authors: Correa Et al.
    Br J Pharmacol  2005;145:441
  31. Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
    Authors: Mathison Et al.
    Br J Pharmacol  2004;142:1247
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