K 579

Catalog # Availability Size / Price Qty
2790/10
2790/50
K 579 | CAS No. 440100-64-1 | DPPIV/CD26 Inhibitors
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Description: Dipeptidyl peptidase IV (DPP-IV) inhibitor

Chemical Name: (2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

Dipeptidyl peptidase IV inhibitor. Inhibits rat, canine, human and monkey enzymes with IC50 values of 3, 5, 8, and 8 nM respectively. Long-acting hypoglycemic agent; attenuates glucose excursion following glucose loading in Zucker fatty rats.

Technical Data

M.Wt:
328.41
Formula:
C17H24N6O
Solubility:
Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
440100-64-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for K 579

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Treat ulcers in vivo
By Yasutada Akiba on 01/04/2018
Application: Species: Rat

Oral once a day treatment is useful to treat small intestinal ulcer model in rats, because of long half life due to enterohepatic circulation.

PMID: 24379150

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