Catalog Number: 2790
Chemical Name: (2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile
Biological Activity
Dipeptidyl peptidase IV inhibitor. Inhibits rat, canine, human and monkey enzymes with IC50 values of 3, 5, 8, and 8 nM respectively. Long-acting hypoglycemic agent; attenuates glucose excursion following glucose loading in Zucker fatty rats.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent.
    Takasaki et al.
    Eur.J.Pharmacol., 2004;486:335
  2. Effects of combination treatment with dipeptidyl peptidase IV inhibitor and sulfonylurea on glucose levels in rats.
    Takasaki et al.
    J.Pharmacol.Sci., 2004;95:291
  3. Involvement of the active metabolites in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV.
    Takasaki et al.
    Eur.J.Pharmacol., 2004;505:237

The citations listed below are publications that use Tocris products. Selected citations for K 579 include:

Showing Results 1 - 1 of 1

  1. Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration.
    Authors: Fujiwara Et al.
    Arterioscler Thromb Vasc Biol
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