K 579

  ( 2 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2790
Chemical Name:(2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile
Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity
Dipeptidyl peptidase IV inhibitor. Inhibits rat, canine, human and monkey enzymes with IC50 values of 3, 5, 8, and 8 nM respectively. Long-acting hypoglycemic agent; attenuates glucose excursion following glucose loading in Zucker fatty rats.
Technical Data
  • M.Wt:
    328.41
  • Formula:
    C17H24N6O
  • Solubility:
    Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    440100-64-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for K 579 include:

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  1. Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration.
    Authors: Fujiwara Et al.
    Arterioscler Thromb Vasc Biol  2015;56:155
  2. Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats.
    Authors: Inoue Et al.
    Dig Dis Sci  2014;59:1286

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Average Rating: 5 (Based on 1 review)

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  Rat Yasutada Akiba 01/04/2018
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Species Rat
Pub Med ID 24379150

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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