Kainic acid (synthetic)
Chemical Name: (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
Biological ActivityKainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC50 = 0.6 μM - 7.4 μM) and a partial agonist at AMPA receptors (EC50 = 31 μM - 170 μM). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. Kainate is shown to be involved in amyloidogenic processing of amyloid precursor protein and Aβ peptides in Alzheimer's. Synthetic version of Kainic acid (Cat. No. 0222)
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Excitatory amino acids.
Kainic acid as a Tool in Neurobiology. Edited by E, 1978;:37
Excitatory amino acid transmitters.
Watkins and Evans
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