Kainic acid (synthetic)

Key Product Details

Product Description

Kainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC₅₀ = 0.6 μM - 7.4 μM) and a partial agonist at AMPA receptors (EC₅₀ = 31 μM - 170 μM). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. Kainate is shown to be involved in amyloidogenic processing of amyloid precursor protein and Aβ peptides in Alzheimer's. Synthetic version of Kainic acid (Cat. No. 0222)

Related compounds include the kainate receptor agonist Domoic acid (Cat. No. 0269) and the antagonist NBQX (Cat. No. 0373).

Product Specifications for Kainic acid (synthetic)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Kainic acid (synthetic)

The following data is based on the product molecular weight 213.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	18.76 mL	93.80 mL	187.59 mL
1.25 mM	3.75 mL	18.76 mL	37.52 mL
2.5 mM	1.88 mL	9.38 mL	18.76 mL
12.5 mM	0.38 mL	1.88 mL	3.75 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Watkins Excitatory amino acids. Kainic acid as a Tool in Neurobiology. Edited by E
• Watkins & Evans Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 1981 PMID: 6112965

Product Documents for Kainic acid (synthetic)