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KD 5170

Catalog #: 4001 Datasheet / COA / SDS

Discontinued Product

4001 has been discontinued.
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KD 5170 | CAS No. 940943-37-3 | Histone Deacetylase Inhibitors
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Description: Class I and II histone deacetylase (HDAC) inhibitor

Chemical Name: S-[2-[6-[[[4-[3-(Dimethylamino)propoxy]phenyl]sulfonyl]amino]-3-pyridinyl]-2-oxoethyl]ethanethioc acid ester

Purity: ≥95%

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Biological Activity

Class I and II histone deacetylase (HDAC) inhibitor (IC50 = 0.045 μM; EC50 = 0.025 μM in HeLa screening and HeLa cell-based assays, respectively). Exhibits broad spectrum inhibition of HDAC classes I and II in assays using purified recombinant human isoforms. Displays less potent inhibition of HDAC2 (IC50 values are 0.014, 0.020, 0.026, 0.075 and 2.0 μM for HDAC6, HDAC1, HDAC4, HDAC3 and HDAC2 respectively). Displays cytotoxicity against numerous cell lines derived from human tumors. Orally available.

Technical Data

M.Wt:
451.56
Formula:
C20H25N3O5S2
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
940943-37-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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