KMT2B Antibody

Novus Biologicals | Catalog # NB300-864

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%), Mouse (100%), Porcine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all KMT2B Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence CNCGAKRCRRFLN corresponding to C-Terminus according to NP_055542.1.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for KMT2B Antibody

Immunohistochemistry-Paraffin: KMT2B Antibody [NB300-864]

Immunohistochemistry-Paraffin: KMT2B Antibody [NB300-864]

Immunohistochemistry-Paraffin: KMT2B Antibody [NB300-864] - (5ug/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Immunohistochemistry-Paraffin: KMT2B Antibody [NB300-864]

Immunohistochemistry-Paraffin: KMT2B Antibody [NB300-864]

Immunohistochemistry-Paraffin: KMT2B Antibody [NB300-864] - (5ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for KMT2B Antibody

Application
Recommended Usage

Immunohistochemistry

5 - 10 ug/ml

Immunohistochemistry-Paraffin

5 - 10ug/ml

Peptide ELISA

detection limit 1:128000
Application Notes
Western blot: Using our routine western blotting protocol we would not expect to reliably detect proteins larger than 250kDa (calculated MWt. of approx. 294KDa according to NP_055542.1).
IHC: Positive staining seen in paraffin embedded Human Testis and Human Brain Cortex.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: KMT2B

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.

Alternate Names

EC 2.1.1.43, histone-lysine N-methyltransferase MLL4, HRX2, KIAA0304WW domain-binding protein 7, Lysine N-methyltransferase 2D, mixed lineage leukemia gene homolog 2, MLL2, myeloid/lymphoid or mixed-lineage leukemia 4, Myeloid/lymphoid or mixed-lineage leukemia protein 4, Trithorax homolog 2, trithorax homologue 2, TRX2, WBP7, WBP-7, WW domain binding protein 7

Entrez Gene IDs

9757 (Human); 75410 (Mouse); 361543 (Rat)

Gene Symbol

KMT2B

UniProt

NP_055542.1 (Human)

Additional KMT2B Products

Product Documents for KMT2B Antibody

Certificate of Analysis

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Product Specific Notices for KMT2B Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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