KuWal151

Catalog # Availability Size / Price Qty
6644/50
6644/10
Cdc2-like Kinase Inhibitors Small Molecule
1 Image
Description: Potent and selective CLK inhibitor

Chemical Name: 3-(3-Chlorophenyl)-6,7-dihydropyrrolo[3,4-g]indol-8(1H)-one

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent and selective CLK inhibitor (IC50 values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range of cancer cell lines in vitro at subnanomolar concentrations.

Technical Data

M.Wt:
282.72
Formula:
C16H11ClN2O
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.
    Walter et al.
    PLoS One, 2018;13:e0196761

Product Datasheets

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