Catalog #: 6644 Datasheet / COA / SDS

Discontinued Product

6644 has been discontinued.
View all Cdc2-like Kinase Inhibitors products.
KuWal151 | CAS No. 2341841-06-1 | Cdc2-like Kinase Inhibitors
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Description: Potent and selective CLK inhibitor

Chemical Name: 3-(3-Chlorophenyl)-6,7-dihydropyrrolo[3,4-g]indol-8(1H)-one

Purity: ≥98%

Product Details

Biological Activity

KuWal151 is a potent and selective CLK inhibitor (IC50 values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range of cancer cell lines in vitro at subnanomolar concentrations.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.
    Walter et al.
    PLoS One, 2018;13:e0196761

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