L-655,708

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1327/10
1327/50
L-655,708 | CAS No. 130477-52-0 | Benzodiazepine Inverse Agonists
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Description: Benzodiazepine inverse agonist; selective for α5-containing GABAA receptors

Chemical Name: 11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, ethyl ester

Product Details
Citations (8)
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Biological Activity

Potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

Technical Data

Formula:
C18H19N3O4
Solubility:
Soluble to 25 mM in DMSO
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
130477-52-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for L-655,708

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