L-655,708

  ( 5 citations )    
Product Datasheet
Catalog Number:1327
Chemical Name:11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, ethyl ester
Product Details
Citations (5)
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Biological Activity
Potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
Technical Data
  • M.Wt:
    341.37
  • Formula:
    C18H19N3O4
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    130477-52-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-655,708 include:

5 Citations: Showing 1 - 5
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  1. Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit.
    Authors: Jaiswal Et al.
    J Neurosci  2015;9:127
  2. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
    Authors: Seifi Et al.
    Stem Cells Dev  2014;34:10361
  3. Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states.
    Authors: Drexler Et al.
    Eur J Pharmacol  2013;703:18
  4. Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys.
    Authors: Rüedi-Bettschen Et al.
    Alcohol Clin Exp Res  2013;37:624
  5. Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms.
    Authors: Penatti Et al.
    J Neurosci  2009;29:12484

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