Potent, selective inverse agonist for the benzodiazepine site of GABAA
receptors containing the α
5 subunit (Ki
= 0.45 nM). Displays 50-100-fold selectivity over GABAA
receptors containing α
3 or α
6 subunits in combination with β
3 and γ
2. Enhances LTP in� a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
Soluble to 25 mM in DMSO
Desiccate at +4°C
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All Tocris products are intended for laboratory research use only.
L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors.
Atack et al.
[3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the α5 subunit.
Quirk et al.
Rat and human hippocampal α5 subunit-containing γ-aminobutyric acidA receptors have α5α3γ2 pharmacological characteristics.
Sur et al.
The citations listed below are publications that use Tocris products. Selected citations for L-655,708 include:
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