Catalog Number: 0781
Chemical Name: 2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine
Biological Activity
Selective and extremely potent 5-HT1D receptor agonist.
Technical Data
  • M.Wt:
    411.48
  • Formula:
    C20H21N5O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    137403-12-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.
Background References
  1. L-694,247: a potent 5-HT1D receptor agonist.
    Beer et al.
    Br.J.Pharmacol., 1993;110:1196
  2. Evidence for presynaptic location of inhibitory 5-HT1Dβ -like autoreceptors in the guinea-pig brain cortex.
    Buhlen et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1996;353:281
  3. [3H]L-694,247 labels the 5-HT1Dβ receptor in pig caudate membranes.
    Heald et al.
    Eur.J.Pharmacol., 1994;264:213
  4. Synthesis and serotonergic activity of 5-(oxadiazoyl)tryptamines: potent agonists of 5-HT1D receptors.
    Street et al.
    J.Med.Chem., 1993;36:1529
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-694,247 include:

1 Citations: Showing 1 - 1

  1. Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor.
    Authors: Bhalla Et al.
    Br J Pharmacol 2001;133:891

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