L-694,247
Chemical Name: 2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine
Purity: ≥98%
Biological Activity
L-694,247 is a selective and extremely potent 5-HT1D receptor agonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
L-694,247: a potent 5-HT1D receptor agonist.
Beer et al.
Br.J.Pharmacol., 1993;110:1196 -
Evidence for presynaptic location of inhibitory 5-HT1Dβ -like autoreceptors in the guinea-pig brain cortex.
Buhlen et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1996;353:281 -
[3H]L-694,247 labels the 5-HT1Dβ receptor in pig caudate membranes.
Heald et al.
Eur.J.Pharmacol., 1994;264:213 -
Synthesis and serotonergic activity of 5-(oxadiazoyl)tryptamines: potent agonists of 5-HT1D receptors.
Street et al.
J.Med.Chem., 1993;36:1529
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Citations for L-694,247
The citations listed below are publications that use Tocris products. Selected citations for L-694,247 include:
3 Citations: Showing 1 - 3
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Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
Diabetologia 2007;50:1743
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Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor.
Authors: Bhalla Et al.
Br J Pharmacol 2001;133:891
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Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery.
Authors: Geerts Et al.
Br J Pharmacol 1999;127:1327
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