receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50
values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D
respectively) and other receptors (pIC50
< 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of Merck, Sharpe and Dohme Ltd.
Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor.
Castro et al.