values are 0.08, 0.2 and 93.13 nM for gerbil, human and rat receptors, respectively). Produces anxiolytic-like effects in the gerbil elevated plus-maze. Exhibits antitumor activity in vitro
. Also decreases HER2 activity and tumor growth in mice bearing HER2+
breast tumors. Orally bioavailable and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of Merck, Sharpe and Dohme Ltd.
Distinct mechanism for antidepressant blockade of central substance P receptors.
Kramer et al.
The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists.
Varty et al.
L-733,060, a novel tachykinin NK1 receptor antagonist; effects in [Ca2+]i mobilisation, cardiovascular and dural extravasation assays.
Seabrook et al.
Substance P autocrine signaling contributes to persistent HER2 activation that drives malignant progression and drug resistance in breast cancer.
Garcia-Recio et al.
Cancer Res., 2013;73:6424
The citations listed below are publications that use Tocris products. Selected citations for L-733,060 hydrochloride include:
Showing Results 1 - 10 of 10