L-745,870 trihydrochloride

Catalog # Availability Size / Price Qty
L-745,870 trihydrochloride | CAS No. 866021-03-6 | Dopamine D4 Receptor Antagonists
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Description: Highly selective D4 antagonist

Chemical Name: 3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride

Purity: ≥99%

Product Details
Citations (13)

Biological Activity

L-745,870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and > 1000-fold selectivity over 5-HT2, D1 and D5 receptors.

Technical Data

Soluble to 100 mM in water
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.

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Citations for L-745,870 trihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for L-745,870 trihydrochloride include:

13 Citations: Showing 1 - 10

  1. Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model.
    Authors: Sharma Et al.
    Nat Commun  2021;12:7293
  2. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
    Authors: Matsui and Alvarez
    Cell Rep  2018;23(13):3852
  3. Is DA transporter-mediated DArgic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel DA transporter variant Val559 transgenic mouse model.
    Authors: Dai Et al.
    J Neurodev Disord  2017;9:38
  4. DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell  2017;16(6):1323
  5. Neurochemical arguments for the use of DA D4 receptor stimulation to improve cognitive impairment associated with schizophrenia.
    Authors: Huang
    Pharmacol Biochem Behav  2017;157:16
  6. Mechanisms underlying the endogenous DArgic inhibition of spinal locomotor circuit function in Xenopus tadpoles.
    Authors: Picton Et al.
    Scientific Reports  2016;6:35749
  7. Activation of D4 DA receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells.
    Authors: Chen Et al.
    Autophagy  2015;65:153
  8. Effects of DA D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas.
    Authors: Jensen
    PLoS One  2015;10:e0146154
  9. Fast oscillatory activity in the anterior cingulate cortex: DArgic modulation and effect of perineuronal net loss.
    Authors: Steullet Et al.
    Front Cell Neurosci  2014;8:244
  10. DA D4 receptor counteracts morphine-induced changes in � opioid receptor signaling in the striosomes of the rat caudate putamen.
    Authors: Suárez-Boomgaard Et al.
    Int J Mol Sci  2014;15:1481


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