L-745,870 trihydrochloride

  ( 10 citations )    
Product Datasheet
Catalog Number:1002
Chemical Name:3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
Product Details
Citations (10)
Reviews
Biological Activity
A highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and > 1000-fold selectivity over 5-HT2, D1 and D5 receptors.
Technical Data
  • M.Wt:
    436.21
  • Formula:
    C18H19N4Cl.3HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    866021-03-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-745,870 trihydrochloride include:

10 Citations: Showing 1 - 10
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  1. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell  2017;16(6):1323
  2. Neurochemical arguments for the use of dopamine D4 receptor stimulation to improve cognitive impairment associated with schizophrenia.
    Authors: Huang
    Pharmacol Biochem Behav  2017;157:16
  3. Mechanisms underlying the endogenous dopaminergic inhibition of spinal locomotor circuit function in Xenopus tadpoles.
    Authors: Picton Et al.
    Scientific Reports  2016;6:35749
  4. Activation of D4 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells.
    Authors: Chen Et al.
    Autophagy  2015;65:153
  5. Effects of Dopamine D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas.
    Authors: Jensen
    PLoS One  2015;10:e0146154
  6. Fast oscillatory activity in the anterior cingulate cortex: dopaminergic modulation and effect of perineuronal net loss.
    Authors: Steullet Et al.
    Front Cell Neurosci  2014;8:244
  7. Dopamine D4 receptor counteracts morphine-induced changes in � opioid receptor signaling in the striosomes of the rat caudate putamen.
    Authors: Suárez-Boomgaard Et al.
    Int J Mol Sci  2014;15:1481
  8. D4 dopamine receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1.
    Authors: Herwerth Et al.
    Cereb Cortex  2012;22:1786
  9. Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test.
    Authors: Basso Et al.
    Neuropsychopharmacology  2005;30:1257
  10. A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein.
    Authors: Okada Et al.
    Hypertension  2005;25:794

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