L-745,870 trihydrochloride

Tocris Bioscience | Catalog # 1002

Highly selective D4 antagonist
Tocris Bioscience

Key Product Details

Description

Highly selective D4 antagonist
View all Dopamine D4 Receptor Antagonists »

Product Description

L-745,870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and > 1000-fold selectivity over 5-HT2, D1 and D5 receptors.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Product Specifications for L-745,870 trihydrochloride

Molecular Weight

436.21

Formula

C18H19N4Cl.3HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride

CAS Number

866021-03-6

PubChem ID

49759035

InChI Key

KJSOYZLYCFYXFC-UHFFFAOYSA-N

SMILES

Cl.Cl.Cl.ClC1=CC=C(C=C1)N1CCN(CC2=CNC3=NC=CC=C23)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 43.62 100

Preparing Stock Solutions for L-745,870 trihydrochloride

The following data is based on the product molecular weight 436.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.46 mL 22.92 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Documents for L-745,870 trihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-745,870 trihydrochloride

For research use only

Citations for L-745,870 trihydrochloride

Customer Reviews for L-745,870 trihydrochloride (1)

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  • Inhibition of Synaptic Transmission in the VP
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 02/02/2020
    L-745870 (100 nM)
    L-745,870 trihydrochloride 1002

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