A highly potent and selective D4
dopamine receptor antagonist; L-745,870 has Ki
values of 0.51, 2300 and 960 nM for D4
subtypes respectively and > 1000-fold selectivity over 5-HT2
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Schizophrenia and L-745, 870 a novel dopamine D4 receptor antagonist.
Bristow et al.
3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human D4 receptor.
Kulagowski et al.
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.
Patel et al.
Human D2 and D4 dopamine receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 r
Pillai et al.
The citations listed below are publications that use Tocris products. Selected citations for L-745,870 trihydrochloride include:
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