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L-779,450

Catalog #: 3185 Datasheet / COA / SDS

Discontinued Product

3185 has been discontinued.
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L-779,450 | CAS No. 303727-31-3 | Raf Kinase Inhibitors
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Description: Potent Raf kinase inhibitor

Chemical Name: 2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol

Purity: ≥99%

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Biological Activity

Potent, ATP-competitive Raf kinase inhibitor (IC50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.

Technical Data

M.Wt:
347.8
Formula:
C20H14ClN3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
303727-31-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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