Catalog Number: 3342
Chemical Name: N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
Biological Activity
Potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2 respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo.
Technical Data
  • M.Wt:
    536.44
  • Formula:
    C27H22BrNO4S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    244101-02-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity relationships of cinnamic acylsulfonamide analogues on human EP3 prostanoid receptor.
    Juteau et al.
    Bioorg.Med.Chem., 2001;9:1977
  2. E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype.
    Clarke et al.
    Br.J.Pharmacol., 2004;141:600
  3. Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon.
    Bassil et al.
    Br.J.Pharmacol., 2008;154:126
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-798,106 include:

4 Citations: Showing 1 - 4
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  1. Exposure to 50 Hz magnetic field modulates GABAA currents in cerebellar granule neurons through an EP receptor-mediated PKC pathway.
    Authors: Yang Et al.
    J Cell Mol Med 2015;19:2413
  2. Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes.
    Authors: Fernández-Galilea Et al.
    J Lipid Res 2012;53:2296
  3. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors.
    Authors: Tunaru Et al.
    Cell Commun Signal 2012;109:9179
  4. Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.
    Authors: Chia Et al.
    BMC Pharmacol 2011;11:10
Average Rating: 4 (Based on 1 review)

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Other Experimental Detailsin vivo survival assay

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