Chemical Name: N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
Biological ActivityL-798,106 is a potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2 respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo.
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Structure-activity relationships of cinnamic acylsulfonamide analogues on human EP3 prostanoid receptor.
Juteau et al.
E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype.
Clarke et al.
Activation of prostaglandin EP receptors by lubipro. in rat and human stomach and colon.
Bassil et al.
Citations for L-798,106
The citations listed below are publications that use Tocris products. Selected citations for L-798,106 include:
7 Citations: Showing 1 - 7
Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients.
Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses.
Authors: Ye Et al.
Endocr Connect 2018;7:749
Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
Authors: Perkins Et al.
Exposure to 50 Hz magnetic field modulates GABAA currents in cerebellar granule neurons through an EP receptor-mediated PKC pathway.
Authors: Yang Et al.
J Cell Mol Med 2015;19:2413
Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes.
Authors: Fernández-Galilea Et al.
J Lipid Res 2012;53:2296
Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors.
Authors: Tunaru Et al.
Cell Commun Signal 2012;109:9179
Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.
Authors: Chia Et al.
BMC Pharmacol 2011;11:10
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in vivo survival assay