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L-NNA

Catalog #: 0664
6 Citations 1 Review Datasheet / COA / SDS

Discontinued Product

0664 has been discontinued.
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L-NNA | CAS No. 2149-70-4 | Additional NOS Inhibitors
1 Image
Description: NOS inhibitor (nNOS = eNOS >> iNOS)

Chemical Name: NG-Nitro-L-arginine

Purity: ≥99%

Product Details
Citations (6)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NO synthase inhibitor.

Technical Data

M.Wt:
219.2
Formula:
C6H13N5O4
Solubility:
Soluble to 5 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
2149-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo.
    Dwyer et al.
    Biochem.Biophys.Res.Commun., 1991;176:1136
  2. Nitric oxide synthases in mammals.
    Knowles et al.
    Biochem.J., 1994;298:249

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

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Citations for L-NNA

The citations listed below are publications that use Tocris products. Selected citations for L-NNA include:

6 Citations: Showing 1 - 6

  1. Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus.
    Authors: Pigott and Garthwaite
    Front Synaptic Neurosci  2016;8:17
  2. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    J Neurosci  2015;63:383
  3. On the selectivity of neuronal NOS inhibitors.
    Authors: Pigott Et al.
    Br J Pharmacol  2013;168:1255
  4. NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor.
    Authors: Rodríguez-Muñoz Et al.
    Antioxid Redox Signal  2011;14:2413
  5. Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling.
    Authors: Sánchez-Blázquez Et al.
    PLoS One  2010;5:e11278
  6. Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
    Authors: Mathison Et al.
    Br J Pharmacol  2004;142:1247

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nNOS inhibition in cultured brain tissue
By Anonymous on 11/02/2017

Bath application on cultured brain slices to block nNOS in plasticity.

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